Induction of apoptosis by hypertension via endoplasmic reticulum stress

Kidney & Blood Pressure Research
Yingying SunJi Wang

Abstract

Endoplasmic reticulum (ER) stress is one of the intrinsic apoptosis pathways, and cardiac apoptosis can occur in cardiovascular diseases, such as hypertension. However, the mechanisms by which ER stress leads to apoptosis remain enigmatic, particularly in the progression from cardiac hypertrophy to diastolic heart failure due to hypertension. We used spontaneously hypertensive rats (SHRs) to investigate possible signalling pathways for ER stress. We found that cardiac protein and mRNA levels of glucoseregulated protein 78 were up-regulated. In addition, the CHOP- and caspase-12-dependent pathways, but not that of JNK, were activated in the SHR rats. These results suggest that ER stress can contribute to myocardial apoptosis during hypertensive disease.

Citations

Mar 9, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Safaa NaielJeffrey G Dickhout
Oct 4, 2019·The Journal of Pharmacy and Pharmacology·Nur Banu BalEmine Demirel-Yilmaz
Sep 19, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michał BiernackiElżbieta Skrzydlewska
Dec 22, 2017·Journal of Cellular and Molecular Medicine·Li JinMyung Ho Jeong

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