PMID: 11927004Apr 3, 2002Paper

Induction of apoptosis by sulindac in azoxymethane-induced possible colonic premalignant lesions in rats

Japanese Journal of Cancer Research : Gann
Toshiya KunoHideki Mori

Abstract

We have reported that beta-catenin-accumulated crypts (BCAC), which do not have the appearance of aberrant crypt foci (ACF) are possible colonic premalignant lesions in rats. Suppression of the occurrence and advancement of such lesions should have critical relevance to cancer prevention. This study examined whether sulindac, a chemopreventive nonsteroidal anti-inflammatory drug is able to induce apoptosis in such premalignant lesions. At 6 weeks of age, rats groups 1 - 3 were given azoxymethane (AOM) (15 mg/kg-body weight) once weekly for 3 weeks. Two groups were given sulindac in the diet (200 and 400 ppm), starting at 9 weeks of age. The rats were sacrificed at the termination, and the colons were carefully examined. The incidence and crypt multiplicity of BCAC and ACF were significantly less than those of the control group. The effect of sulindac on the expression of BCAC was greater than that on ACF. Exposure to sulindac significantly increased the apoptotic index (terminal deoxynucleotide transferase dUTP nick-end labeling (TUNEL)-positive cells) in BCAC. However, no significant increase of the index was found in the case of ACF. These results suggest that the chemopreventive effect of sulindac in rats is related to the i...Continue Reading

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Dec 15, 1991·The New England Journal of Medicine·M J ThunC W Heath
Dec 5, 1991·The New England Journal of Medicine
Jun 13, 1991·The New England Journal of Medicine·P M Brooks, R O Day
Apr 18, 1994·Annals of the New York Academy of Sciences·W L SmithD L DeWitt
May 6, 1993·The New England Journal of Medicine·F M GiardielloG J Offerhaus
Mar 29, 2000·CA: a Cancer Journal for Clinicians·R T GreenleeP A Wingo

❮ Previous
Next ❯

Citations

Dec 17, 2009·Investigational New Drugs·Pandurangan Ashokkumar, Ganapasam Sudhandiran
Nov 28, 2008·Carcinogenesis·Daniel W RosenbergTakuji Tanaka
May 21, 2005·Chemico-biological Interactions·Hideki MoriAkira Hara
Apr 26, 2005·International Journal of Cancer. Journal International Du Cancer·Ying HuGraeme P Young

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.