PMID: 8952869Jan 1, 1996Paper

Induction of apoptosis by ubenimex (Bestatin) in human non-small-cell lung cancer cell lines

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
K EzawaK Dobashi

Abstract

We studied the direct anti-tumor effects of ubenimex on five human lung cancer cell lines; ABC-1, RERF-LC-OK, RERF-LC-MS (adenocarcinoma) and SQ-5, EBC-1 (squamous cell carcinoma). Ubenimex dose-dependently inhibited the growth of these cancer cell lines except RERF-LC-MS. The results indicated that lung squamous cell carcinoma cell lines were more sensitive to ubenimex than lung adenocarcinoma cell lines. Coincidentally, histological observation by Hematoxylin eosine (HE) staining revealed that ubenimex induced nuclear condensation and apoptic body in the cancer cell lines. Immunohistochemical study showed ubenimex-treated cells expressed LeY antigen which is a useful phenotypic marker predictive of apoptosis. The induction of DNA fragmentation was also observed in the ubenimex treated cancer cell lines by ELISA. We conclude that ubenimex exhibits its direct anti-tumor effect against non-small-cell lung cancer cell lines, more effectively against squamous carcinoma cell lines, through the induction of apoptosis.

References

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Citations

Nov 13, 2009·General Thoracic and Cardiovascular Surgery·Shinya ItoFumihiro Tanaka
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Apr 1, 2013·Drug Delivery and Translational Research·Timothy E AndrewsDaniel A Harki
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Dec 15, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhi-Peng SunXue-Jian Wang
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Mar 15, 2006·The Journal of Biological Chemistry·Andrew S CowburnEdwin R Chilvers
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May 16, 2019·EBioMedicine·Simin ZhaoZigang Dong
May 30, 2021·The Journal of Investigative Dermatology·Simin ZhaoZigang Dong
Oct 1, 2008·Bioorganic & Medicinal Chemistry Letters·Michael B HarbutDoron C Greenbaum

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