Induction of apoptosis in murine macrophages by Mycobacterium tuberculosis is reactive oxygen intermediates-independent

Biochemical and Biophysical Research Communications
M RojasL F García

Abstract

Infection with Mycobacterium tuberculosis induces apoptosis in murine macrophage lines. Resistant macrophages B10R (Bcgr) are more prone to undergo apoptosis than susceptible B10S (Bcgs) macrophages. Apoptosis and inhibition of intracellular growth of the mycobacteria seem to be dependent on the production of nitric oxide, since both can be reverted by aminoguanidine (AMG). Although B10R macrophages produce more superoxide anion than B10S macrophages after infection with M. tuberculosis, reactive oxygen intermediate (ROIs) scavengers did not affect uptake of 3H-uracil incorporation by the mycobacteria nor the induction of apoptosis. These results further suggest that both phenomena are dependent on the production of nitric oxide by the infected macrophages.

References

Sep 1, 1990·The Journal of Infectious Diseases·G S JonesB R Andersen
Jul 1, 1988·British Medical Bulletin·D B Lowrie, P W Andrew
Jun 10, 1982·Nature·E SkameneB A Taylor
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Aug 15, 1995·Biochemical and Biophysical Research Communications·T AraiY Yoshikai
Mar 16, 1993·European Journal of Pharmacology·T P MiskoM G Currie
Jan 1, 1994·Immunology Today·T M Buttke, P A Sandstrom
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·D M MonackS Falkow
Sep 1, 1996·Molecular Microbiology·L M ChenJ E Galán
Dec 1, 1996·Infection and Immunity·A ZychlinskyP J Sansonetti
Mar 14, 1997·The Journal of Biological Chemistry·B BrüneE G Lapetina

❮ Previous
Next ❯

Citations

Nov 20, 2001·American Journal of Respiratory Cell and Molecular Biology·E D ChanN W Schluger
Jul 20, 2006·Apoptosis : an International Journal on Programmed Cell Death·Daniel P Barry, Blaine L Beaman
Dec 11, 2008·Immunologic Research·Adam D Kennedy, Frank R DeLeo
Mar 5, 2009·Yonsei Medical Journal·Jinhee LeeHardy Kornfeld
May 13, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Adam LamSaurabh Aggarwal
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S KausalyaM B Prystowsky
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jinhee LeeHardy Kornfeld
Feb 2, 2021·Frontiers in Cellular and Infection Microbiology·Suji KimHan Sang Yoo
Dec 28, 1999·Microbes and Infection·G R Strohmeier, M J Fenton
Jun 12, 2010·Cellular Immunology·Elizabeth Escobar-AlvarezMauricio Rojas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis