PMID: 9523724Apr 2, 1998Paper

Induction of aromatase activity in human adipose tissue stromal cells by extracellular nucleotides--evidence for P2-purinoceptors in adipose tissue

European Journal of Biochemistry
M Schmidt, G Löffler

Abstract

Here we describe properties of the P2-purinoceptor, which is involved in the regulation of the key enzyme of estrogen biosynthesis, aromatase cytochrome P-450, in stromal cells from human adipose tissue. Aromatase activity induced by cortisol and platelet-derived growth factor BB (PDGF-BB) is further increased by addition of ATP, ADP, AMP and, albeit with reduced potency, adenosine, GTP and adenosine(5')tetraphospho(5') adenosine. Stable P1-purinoceptor agonists are inactive, whereas P2X-purinoceptor agonists mimic the effects of purine(s) (nucleotides). Prior incubation of cells with a P2-purinoceptor antagonist, but not P1-purinoceptor antagonists, blocks augmentation of aromatase activity by all ligands. Nucleotides, but not adenosine, retain their ability to augment aromatase activity in the presence of adenosine deaminase, indicating that they do not act via their metabolite adenosine. These results lead to the conclusion, that at least one member of the P2-subclass of purinoceptors exists in adipose tissue and is involved in modulation of aromatase activity in vitro. The pharmacological profile of the P2-site differs from those reported for cloned P2-purinoceptors, but is similar to that of the P2X-subclass. Therefore, a ...Continue Reading

Citations

Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·M WestJ R Nevins
Jul 12, 2011·Stem Cells and Development·Nina ZippelEdda Tobiasch
Mar 30, 2010·Acta Physiologica·G BurnstockA Verkhratsky
Sep 12, 2013·Journal of Molecular Endocrinology·Jan WildeMartin Schmidt
Nov 23, 2013·Purinergic Signalling·Geoffrey Burnstock
Dec 20, 2012·Journal of Pregnancy·Ousseynou SarrTimothy R H Regnault
Apr 8, 2015·Steroids·Jiehan LiVeera Vihma
Sep 11, 2004·Biochemical and Biophysical Research Communications·Johannes SchödelMartin Schmidt
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Mar 2, 2006·Pharmacological Reviews·Geoffrey Burnstock
Mar 17, 2020·Adipocyte·Mingzhu ZhaiWuping Sun

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