PMID: 15378999Sep 24, 2004Paper

Induction of aryl hydrocarbon receptor-mediated and estrogen receptor-mediated activities, and modulation of cell proliferation by dinaphthofurans

Environmental Toxicology and Chemistry
Jan VondrácekMiroslav Machala

Abstract

A group of heterocyclic aromatic compounds, dinaphthofurans (DNFs), recently have been identified as potentially significant contaminants in freshwater sediments. In the present study, a battery of in vitro assays was used for detection of toxic effects of DNFs that are potentially associated with endocrine disruption and tumor promotion. Dinaphthofurans were found to act as relatively potent inducers of aryl hydrocarbon receptor (AhR)-mediated activity in the chemical-activated luciferase reporter gene expression DR-CALUX assay. The relative AhR-inducing potencies of DNFs were similar or even higher than relative potencies of unsubstituted polycyclic aromatic hydrocarbons (PAHs), with dinaphtho[1,2-b;2'3'-d]furan being the most potent AhR agonist. Two compounds, dinaphtho[2,1-b;2'3'-d]furan and dinaphtho[1,2-b;1'2'-d]furan, induced estrogen receptor (ER)-mediated activity in the estrogen receptor-mediated CALUX (the ER-CALUX) assay. Two types of potential tumor-promoting effects of DNFs were investigated, using in vitro bioassays for detection of inhibition of gap-junctional intercellular communication and detection of a release from contact inhibition. Although the acute inhibition of gap-junctional intercellular communicatio...Continue Reading

Citations

Dec 1, 2012·Archives of Toxicology·Dagmar FaustMiroslav Machala
Mar 25, 2011·Environmental Science and Pollution Research International·Gunnar HingerHenner Hollert
May 6, 2006·Environmental Health Perspectives·Gail P KleinPatricia A Harper
Feb 17, 2009·Ecotoxicology and Environmental Safety·María Victoria PablosJosé Vicente Tarazona
Sep 20, 2016·Environmental Science & Technology·Hongxia XiaoHenner Hollert
Sep 20, 2008·Environmental Science & Technology·Ewa SkoczyńskaJacob De Boer
Aug 28, 2021·International Journal of Molecular Sciences·Iva SovadinováPavel Babica

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