PMID: 323406May 1, 1977

Induction of autoimmunity in good and poor responder mice with mouse thyroglobulin and lipopolysaccharide

The Journal of Experimental Medicine
P S EsquivelY C Kong

Abstract

The administration of soluble mouse thyroglobulin (MTg) in conjunction with bacterial lipopolysaccharide (LPS) led to the termination of natural tolerance to MTg in mice. The extent of autoimmunity correlated with responsiveness to MTg, previously shown by the injection of MTg in complete Freund's adjuvant (CFA) to be dependent upon the H-2 haplotype. In good responder B10.BR (H-2k) mice given MTg either with LPS or in CFA, high antibody levels to MTg and extensive mononuclear cell infiltration in the thyroid were observed. In contrast, congenic poor responder B10.D2 (H-2d) mice given MTg plus LPS showed low levels of antibody to MTg, compared to those receiving MTg in CFA, and insignificant cellular infiltration of the thyroid. In no instance did autoimmunity develop in either good or poor responder strain given MTg, LPS, or CFA along although LPS was antigenic in both of these congenic strains. Since the genetic difference in responsiveness to MTg is known to be T-cell based, the involvement of T cells in LPS-treated mice was suspected. This was further ascertained by the use of athymic poor responder (BALB/c) mice and thymectomized, irradiated, and bone marrow-reconstituted B10.BR mice. Antibodies to MTg were detected only i...Continue Reading

References

Nov 1, 1975·Cellular Immunology·M Small, N Trainin
Oct 7, 1976·The New England Journal of Medicine·A C Allison
Dec 25, 1971·Lancet·A C Allison
Mar 30, 1974·Cellular Immunology·Y M Kong, S L Capanna
Aug 1, 1972·The Journal of Experimental Medicine·J R Schmidtke, F J Dixon
Feb 1, 1974·The Journal of Experimental Medicine·M F KagnoffM Cohn
Mar 1, 1974·The Journal of Experimental Medicine·J A Clagett, W O Weigle
Dec 10, 1971·Science·A O Vladutiu, Noel R Rose
Jan 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·F J TwarogNoel R Rose
Mar 1, 1969·The Journal of Clinical Endocrinology and Metabolism·G TorrigianiI M Roitt

Citations

Jun 26, 1999·European Journal of Immunology·P ZacconeA Cooke
Sep 24, 2004·Reviews in Medical Virology·DeLisa FairweatherNoel R Rose
Feb 15, 2008·Cancer Immunology, Immunotherapy : CII·Wei-Zen WeiYi-chi M Kong
Jun 21, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Samuel W Hall, A Cooke
Jan 3, 1983·Life Sciences·Noel R Rose, Y M Kong
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·C Daniel-RibeiroM Gentilini
Jan 15, 1989·Immunology Letters·L S RayfieldL A Bergmeier
Feb 1, 1997·Immunology Today·George Carayanniotis, V P Rao
Jan 1, 1996·Journal of Endocrinological Investigation·N AminoY Hidaka
Jul 14, 1999·Biochimie·A Krogh RasmussenU Feldt-Rasmussen
Feb 1, 1983·The Journal of Experimental Medicine·P CreemersY M Kong
Jul 1, 1986·The Journal of Experimental Medicine·D PortnoïA Coutinho
Mar 1, 1992·The Journal of Experimental Medicine·P R HutchingsI M Roitt
Aug 10, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Balaji B GaneshBellur S Prabhakar
Jan 1, 1992·Thyroid : Official Journal of the American Thyroid Association·A Martin, T F Davies
Jul 23, 2011·PloS One·Balaji B GaneshBellur S Prabhakar
Nov 20, 2004·Emerging Infectious Diseases·DeLisa Fairweather, Noel R Rose
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·T GermannE Rüde
Dec 29, 2000·International Reviews of Immunology·E A Stafford, Noel R Rose
Dec 29, 2000·International Reviews of Immunology·H Braley-Mullen, G C Sharp
Jan 1, 1988·Autoimmunity·Noel R Rose
Jun 21, 2011·Journal of Autoimmunity·Noel R Rose
Oct 13, 2009·Journal of Autoimmunity·C Lynne Burek, Monica V Talor
Oct 14, 2009·Journal of Autoimmunity·Yi-chi M KongChella S David
Aug 18, 2009·Journal of Autoimmunity·Aftab A Ansari, M Eric Gershwin
Sep 1, 1989·Clinical Immunology and Immunopathology·M J MamulaJ A Hardin
Jan 1, 1982·Annals of the New York Academy of Sciences·Y M KongL Chedid
Aug 1, 1982·Journal of Immunogenetics·K W BeiselNoel R Rose
Aug 19, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Naoko ArataT F Davies
Feb 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·G Möller
Jan 1, 1981·Immunological Reviews·Noel R RoseR S Sundick
Jun 2, 2005·Journal of Autoimmunity·Evangelos KarrasPremkumar Christadoss
Aug 31, 2014·Journal of Theoretical Biology·Noel R Rose
Mar 1, 1981·Immunology Today·M G Goodman, W O Weigle
Jan 1, 1981·Immunological Communications·A O Vladutiu, M B Zaleski
Jun 1, 1983·Immunology Today·A CookeI M Roitt
Apr 1, 1978·Cellular Immunology·P S EsquivelNoel R Rose
Aug 1, 1981·Clinical Immunology and Immunopathology·I OkayasuNoel R Rose
Oct 16, 1999·The Journal of Biological Chemistry·M MarinòD Andrews
Aug 2, 2001·Nature Medicine·P MarrackB L Kotzin
Oct 5, 2013·Endocrine Reviews·Sandra M McLachlan, Basil Rapoport
Apr 23, 1999·The Journal of Biological Chemistry·M MarinòR T McCluskey
Jun 28, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vincent van DrongelenJoseph Holoshitz
Jan 1, 1994·Autoimmunity·N M WagleBellur S Prabhakar
May 11, 2006·Immunopharmacology and Immunotoxicology·Bong-Seok KangCheorl-Ho Kim
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pavel N PichurinSandra M McLachlan
Jan 15, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Panayota KolypetriGeorge Carayanniotis
Aug 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea P MartinSergio A Lira
May 1, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anupama GopisettyBellur S Prabhakar
Feb 1, 1981·European Journal of Immunology·M ElRehewyNoel R Rose
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gerald P MorrisYi-chi M Kong
May 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas K BrownYi-chi M Kong
Apr 25, 2008·Current Protocols in Immunology·Yi-chi M Kong
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laia MuixíDolores Jaraquemada
Jan 1, 1988·European Journal of Immunology·R C KuppersNoel R Rose
Dec 1, 1988·The American Journal of Physiology·E J SorscherD J Benos
Jul 20, 2007·Cancer Research·Jennifer B JacobWei-Zen Wei

Related Concepts

Immunologic Adjuvants
Antigens
Autoantibodies
Bone Marrow Cells
SD Antigens
Natural Immunosuppression
Kidney
Liver
Mice, Nude
Polysaccharides, Bacterial

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.