Induction of autoimmunity through bystander effects. Lessons from immunological disorders induced by heavy metals

Journal of Autoimmunity
G J FourniéP Druet

Abstract

Autoreactive T cells exist in healthy individuals and represent a potential reservoir of pathogenic effectors which, when stimulated by microbial adjuvants, could trigger an autoimmune disease. Experimental studies have indicated that xenobiotics, well defined from a chemical point of view, could promote the differentiation of autoreactive T cells towards a pathogenic pathway. It is therefore theoretically possible that compounds present in vaccines such as thiomersal or aluminium hydroxyde can trigger autoimmune reactions through bystander effects. Mercury and gold in rodents can induce immunological disorders with autoimmune reactions. In vitro, both activate signal transduction pathways that result in the expression of cytokines, particularly of IL-4 and IFNgamma. In a suitable microenvironment heavy metals could therefore favour the activation of autoreactive T cells. In that respect, genetic background is of major importance. Genome-wide searches in the rat have shown that overlapping chromosomal regions control the immunological disorders induced by gold salt treatment, the development of experimental autoimmune encephalomyelitis and the CD45RC(high)/CD45RC(low)CD4(+)T cells balance. The identification and functional char...Continue Reading

References

Apr 1, 1992·Scientific American·H M JohnsonC H Pontzer
Jan 1, 1991·Research in Immunology·F PowrieD Mason
Jan 1, 1991·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H TournadeL Pelletier
Apr 1, 1991·Immunology Today·I R Cohen, D B Young
Apr 6, 1995·Nature·A M KriegD M Klinman
Jan 1, 1995·Clinical Immunology and Immunopathology·M Kotb
Dec 31, 1997·The Journal of Experimental Medicine·R S ChuC V Harding
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·C L Brazolot MillanH L Davis
Mar 2, 1999·The Journal of Experimental Medicine·B Seddon, D Mason
Jul 19, 2000·Current Opinion in Immunology·V E Schijns

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Citations

Apr 1, 2006·Journal of Toxicology and Environmental Health. Part a·P HultmanK M Pollard
Aug 21, 2002·Thyroid : Official Journal of the American Thyroid Association·T Akamizu
Apr 16, 2005·Blood Purification·Donald A Molony, Bhamidipati Murthy
Jan 7, 2011·Journal of Thyroid Research·Marco CappaFrancesca Crea
Nov 22, 2011·Journal of Inorganic Biochemistry·Lucija Tomljenovic, Christopher A Shaw
Dec 26, 2009·Journal of Autoimmunity·Yinon ShapiraYehuda Shoenfeld
Dec 22, 2009·Journal of Autoimmunity·Yaron Tomer
Mar 25, 2009·Journal of Autoimmunity·Yaron Tomer, Amanda Huber
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yannie Oi-Yan SooPhilip Kam-Tao Li
Jul 2, 2005·Autoimmunity Reviews·Said Havarinasab, Per Hultman
Sep 3, 2004·The Journal of Allergy and Clinical Immunology·Stephan WeidingerHeidrun Behrendt
Aug 19, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Naoko ArataTerry F Davies
Feb 3, 2004·Immunology and Allergy Clinics of North America·Romain K Gherardi, François-Jérôme Authier
Jul 19, 2005·Toxicology and Applied Pharmacology·Ellen K SilbergeldJennifer F Nyland
Jul 16, 2016·Immunologic Research·Jiram Torres RuizYehuda Shoenfeld
Sep 15, 2004·La Revue de médecine interne·B Bonnotte
May 16, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Angela Kallwellis-OparaMathias Pauschinger
Nov 3, 2006·Journal of Leukocyte Biology·Anshu AgrawalSudhir Gupta
Aug 15, 2002·Circulation·Maurizio GabrielliAntonio Gasbarrini
Sep 29, 2006·Journal of Cellular Biochemistry·Tatjana PauneskuGayle Woloschak
Oct 30, 2008·Journal of Immunotoxicology·Janine EzendamRaymond Pieters
Sep 4, 2008·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Maria Antonia PouCesar Diaz-Lopez
Apr 6, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Vasco BrancoCristina Carvalho
Apr 1, 2013·Auto- Immunity Highlights·Daniel SmykDimitrios P Bogdanos
Nov 17, 2016·Frontiers in Microbiology·Andrew C SingerAlwyn Hart
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Markus H HoffmannGünter Steiner
May 1, 2010·Auto- Immunity Highlights·Barbara C Böckle, Norbert T Sepp

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