Induction of BCL2-Interacting Killer, BIK, is Mediated for Anti-Cancer Activity of Curcumin in Human Head and Neck Squamous Cell Carcinoma Cells

Journal of Cancer
Yue XiYu-Lin Li

Abstract

Naturally occurring diarylheptanoid curcumin (CUR), a principal component of the Asian spice turmeric, has been shown to have anti-cancer effects in many tumor types. However, a detailed mechanism regarding CUR induced tumor cell killing remain to be comprehensively explored. Using two head neck squamous cell carcinoma (HNSCC) cell lines FaDu (hypopharyngeal) and Cal27 (tongue), we demonstrated a novel mechanism by which CUR levies the cytotoxic effect. We found that CUR induced upregulation of pro-apoptotic Bik, down-regulation of survival signaling by AKT and NF-κB prior to the induction of the caspase-cascade reduction of cell proliferation, are primary mechanisms of CUR-induced cell death, thus providing insights into the anti-tumor activity of CUR in HNSCC cells.

Citations

May 25, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Gabriel Álvares BorgesEliete Neves Silva Guerra
Aug 17, 2016·Nutrients·Jie ZhengHua-Bin Li
Nov 23, 2016·Critical Reviews in Food Science and Nutrition·Muhammad ImranHafiz Ansar Rasul Suleria
Apr 1, 2017·Journal of Experimental & Clinical Cancer Research : CR·Lihua WangTongke Chen
Nov 5, 2020·Recent Patents on Anti-cancer Drug Discovery·Saleh A AlmatroodiArshad Husain Rahmani

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Methods Mentioned

BETA
dissection
xenograft

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Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

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