PMID: 7540298Jun 1, 1995Paper

Induction of benign prostatic hyperplasia in intact dogs by near-physiological levels of 5 alpha-dihydrotestosterone and 17 beta-estradiol

The Prostate
M L WinterJ G Liehr

Abstract

Benign prostatic hyperplasia was induced in mongrel dogs treated for 60 days with one silastic implant containing 17 beta-estradiol and four containing 5 alpha-dihydrotestosterone. The condition was characterized by (1) a marked increase of the stromal elements, particularly the stromal septa between the individual glands, (2) a slight increase in prostatic volume, and (3) a morphology that resembled spontaneous complex benign prostatic hyperplasia in the dog. Other groups of animals that remained untreated or received only 17 beta-estradiol or only 5 alpha-dihydrotestosterone did not develop this condition. Prostate volumes decreased by 14% in the estrogen-treated dogs, whereas they increased in the androgen-treated animals by 6% compared to pretreatment prostate volumes. The morphology of the epithelium of the prostates of androgen-treated animals was not different from that of controls despite the increase in prostate volume. The serum 17 beta-estradiol and 5 alpha-dihydrotestosterone concentrations were increased from 25 +/- 2 (mean +/- SEM) and 256 +/- 42 pg/mL, respectively, in control dogs to 52 +/- 37 and 562 +/- 37 pg/mL, respectively, in the dogs treated with the hormone combination. Thus, hormone concentrations were ...Continue Reading

References

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Citations

Jun 22, 2000·The Prostate·D J WatersL T Glickman
May 20, 1999·Baillière's Clinical Endocrinology and Metabolism·R S Swerdloff, C Wang
Oct 17, 2001·Journal of the American College of Nutrition·G A BrownD S King
May 31, 2011·Differentiation; Research in Biological Diversity·Tristan M Nicholson, William A Ricke
Aug 5, 2006·Medicine and Science in Sports and Exercise·Gregory A BrownDouglas S King
May 10, 2007·American Journal of Physiology. Endocrinology and Metabolism·Stephen E BorstThomas J Wronski
Apr 1, 1997·Annals of Medicine·H Adlercreutz, W Mazur
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Christina Wang, Ronald S Swerdloff
Dec 18, 2001·Journal of Applied Physiology·Gregory A BrownDouglas S King

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