Induction of beta-cell rest in type 1 diabetes. Studies on the effects of octreotide and diazoxide

Diabetes Care
E BjörkF A Karlsson

Abstract

To evaluate the inhibitory effects of octreotide and diazoxide on insulin secretion in patients with type 1 diabetes and measurable levels of circulating C-peptide. Diazoxide was given to six patients during a 7-day period (100 mg three times daily), followed by a 3-week washout. Subsequently, octreotide (50 micrograms, three times daily) was administered subcutaneously for 7 days. Pre- and post- prandial blood glucose and serum C-peptide concentrations were measured before medication (control) and on day 7 of each medication period. Glucagon-stimulated C-peptide was determined in the morning before medication and on the day after each treatment period. Diazoxide inhibited glucagon-stimulated C-peptide secretion (mean increment 0.08 nmol/l vs. 0.18 nmol/l, P < 0.05), whereas octreotide had no such effect. Both reduced the pre- and postprandial serum C-peptide concentrations (P < 0.05), octreotide being the more potent in this respect. A reduction in basal and meal-related blood glucose was observed during octreotide treatment, whereas the glucose concentrations tended to be higher during treatment with diazoxide than during the 24-h control period. The study indicates that the two drugs reduce insulin output by different mechan...Continue Reading

Citations

Dec 15, 2011·American Journal of Physiology. Endocrinology and Metabolism·Christopher J LynchJochen Antel
Jan 29, 2008·Pediatric Diabetes·Rebecca J Brown, Kristina I Rother
Nov 13, 2004·Hormone Research·K Maedler, M Y Donath
Jan 12, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·A SchölinUNKNOWN Diabetes Incidence Study Group in Sweden (DISS)
Nov 30, 2000·Upsala Journal of Medical Sciences·F A KarlssonL Zhao

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