PMID: 6974819Jan 1, 1981Paper

Induction of bone resorption by parathyroid hormone in congenital malignant osteopetrosis

Metabolic Bone Disease & Related Research
F H GlorieuxN Shepard

Abstract

A male patient, afflicted with malignant congenital osteopetrosis, was studied over a 5 year period. Hypocalcemia (less than 8 mg/dl) with lack of an appropriate increase in serum immunoreactive parathyroid hormone (iPTH) prevailed at all times. Under a calcium restricted diet, a 6-hour infusion of parathyroid extract normalized serum calcium, and increased the urinary hydroxyproline excretion suggesting that bone resorption had been induced. A second attempt to induce resorption was made by infusing a synthetic amino terminal fragment of bovine PTH over a period of 3 weeks at the dose of 1.5 units/kg/hr. This infusion evoked an increase in serum calcium (8.1 to 10.5 mg/dl), urinary calcium (0.03 to 0.65 mg/g creatinine) and urinary hydroxyproline (160 to 372 mg/g creatinine); and urinary hydroxyproline (160 to 372 mg/g creatinine); increases which were reversed by calcitonin administration. Iliac crest bone biopsies were obtained before and on the last day of the 3-week infusion. Quantitative comparison of the two specimens showed that, during PTH infusion, there was a 23% decrease in bone volume due to the increase in marrow space, a 93% increase in the number of osteoclasts and 136% increment in the osteoclastic resorption s...Continue Reading

References

Sep 1, 1976·Archives of Biochemistry and Biophysics·J A EismanH F DeLuca
Jan 1, 1979·Acta Paediatrica Scandinavica. Supplement·D AarskogK Julshamn
Oct 1, 1978·The Journal of Clinical Endocrinology and Metabolism·R K RudeF R Singer
Feb 1, 1979·The Journal of Pediatrics·J D ReevesC E Walters
Dec 1, 1971·The Journal of Clinical Endocrinology and Metabolism·J G Haddad, K J Chyu
May 1, 1972·Journal of Ultrastructure Research·D M KallioC Minkin
Oct 27, 1972·Annals of the New York Academy of Sciences·J W Estes
May 25, 1973·Science·D G Walker
Nov 1, 1969·Acta paediatrica Scandinavica·P J Moe, A Skjaeveland
Jan 1, 1971·The Journal of Clinical Investigation·C D ArnaudT Littledike
Mar 27, 1980·The New England Journal of Medicine·P F CocciaD M Brown
Feb 1, 1965·Archives of Disease in Childhood·C E DENTL WATSON

❮ Previous
Next ❯

Citations

Aug 1, 1988·Calcified Tissue International·F ShapiroC Anast
Oct 6, 2009·Bone Marrow Transplantation·C MartinezP J Orchard
Feb 16, 1984·The New England Journal of Medicine·L KeyA Kahn
Jul 5, 1984·The New England Journal of Medicine·B R BlazarD M Brown
Jul 1, 1986·Archives of Disease in Childhood·L M DorantesS Dorantes
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M IacobiniA Teti
Oct 1, 1993·European Journal of Pediatrics·E M van Lie PetersL J Dooren
Jan 1, 2003·The American Journal of Pathology·Anna TarantaAnna Teti
Oct 11, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Florian BarvencikMichael Amling
Feb 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B G MillsF R Singer
Jan 16, 1999·Journal of Pediatric Orthopedics·D G ArmstrongR Gillespie
Sep 1, 1989·American Journal of Medical Genetics·S C Marks
Sep 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N S Krieger
Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C L ShortN S Krieger
Jan 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G CournotM Garabedian
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·P van TranA Ryckewaert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Metabolic Bone Disease & Related Research
S L TeitelbaumA J Kahn
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
S N PopoffS C Marks
© 2021 Meta ULC. All rights reserved