Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.

Neuro-oncology
Adriana Estrada-BernalJames R Van Brocklyn

Abstract

FTY720 is a sphingosine analogue that down regulates expression of sphingosine-1-phosphate receptors and causes apoptosis of multiple tumor cell types, including glioma cells. This study examined the effect of FTY720 on brain tumor stem cells (BTSCs) derived from human glioblastoma (GBM) tissue. FTY720 treatment of BTSCs led to rapid inactivation of ERK MAP kinase, leading to upregulation of the BH3-only protein Bim and apoptosis. In combination with temozolomide (TMZ), the current standard chemotherapeutic agent for GBM, FTY720 synergistically induced BTSC apoptosis. FTY720 also slowed growth of intracranial xenograft tumors in nude mice and augmented the therapeutic effect of TMZ, leading to enhanced survival. Furthermore, the combination of FTY720 and TMZ decreased the invasiveness of BTSCs in mouse brains. FTY720 is known to cross the blood-brain barrier and recently received Food and Drug Administration approval for treatment of relapsing multiple sclerosis. Thus, FTY720 is an excellent potential therapeutic agent for treatment of GBM.

References

Feb 22, 2001·Biochemical and Biophysical Research Communications·Y SonodaT Kasahara
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Sompol PermpongkosolAkihiko Okuyama
Jan 18, 2003·Biochimica Et Biophysica Acta·Michael MaceykaSarah Spiegel
May 3, 2003·Nature Reviews. Molecular Cell Biology·Sarah Spiegel, Sheldon Milstien
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
Nov 24, 2004·Oncogene·Xiangpeng YuanJohn S Yu
Jun 30, 2005·International Journal of Cancer. Journal International Du Cancer·Chee-Wai ChuaYong-Chuan Wong
Aug 17, 2005·Cancer Research·Hiroshi YasuiKenneth C Anderson
Jun 6, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Guy M L Meno-TetangWilliam J Jusko
Oct 7, 2006·British Journal of Cancer·R A Sabbadini
Jun 15, 2007·Critical Reviews in Oncology/hematology·Andrea Huwiler, Uwe Zangemeister-Wittke
Jun 29, 2007·Expert Reviews in Molecular Medicine·Tip W Loo, David M Clarke
Aug 30, 2007·The Journal of Pharmacology and Experimental Therapeutics·Rochelle P CoelhoCarmen Sato-Bigbee
Aug 30, 2007·World Journal of Surgery·Simon A W G DelloCornelis H C Dejong
Oct 4, 2007·Journal of Biochemical and Molecular Toxicology·Donald A VesseyJoel S Karliner
Oct 6, 2007·Annals of Neurology·Veronique E MironJack P Antel
Oct 16, 2007·Expert Reviews in Molecular Medicine·Mandi Murph, Gordon B Mills
Dec 20, 2007·Expert Reviews in Molecular Medicine·Emilie FugierJean-Pierre Gorvel
May 27, 2008·Cancer Treatment Reviews·Tor-Christian Aase JohannessenBerit Bølge Tysnes
Jul 16, 2008·Expert Opinion on Therapeutic Targets·Olivier Cuvillier
Aug 6, 2008·Journal of the Neurological Sciences·Veronique E MironJack P Antel
Aug 12, 2008·Current Drug Targets·Dai ShidaSarah Spiegel
Aug 30, 2008·Sub-cellular Biochemistry·Sahar A SaddoughiBesim Ogretmen
Sep 6, 2008·The American Journal of Pathology·Veronique E MironJack P Antel
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun LiMengfeng Li
Feb 14, 2009·Pathology Oncology Research : POR·Natália R SalinasValquiria Bueno

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Citations

Jun 20, 2013·Behavioural Brain Research·Fatemeh HemmatiAbolhassan Ahmadiani
Dec 7, 2013·PloS One·Kanako HagiharaReiko Sugiura
Aug 8, 2014·Experimental Brain Research·Rana OmidbakhshLeila Dargahi
Aug 8, 2013·Future Medicinal Chemistry·Jiawang LiuMaryam Foroozesh
Mar 14, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Justin SharimNader Pouratian
Mar 23, 2013·British Journal of Pharmacology·A SinclairT L Holyoake
Feb 11, 2014·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kanako HagiharaReiko Sugiura
Jul 15, 2015·Journal of Cellular and Molecular Medicine·Sathya Narayanan PatmanathanIan C Paterson
Jun 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Karl QuintMalgorzata Anna Kolodziej
May 9, 2015·Journal of Neuroinflammation·Raffaela CiprianiCarlos Matute
Mar 20, 2015·Frontiers in Neurology·Domenico PlantoneTatiana Koudriavtseva
Oct 14, 2014·Frontiers in Cellular Neuroscience·Robert BrunkhorstWaltraud Pfeilschifter
Nov 9, 2016·Neuropharmacology·Sinead O'Sullivan, Kumlesh K Dev
Mar 16, 2017·The Journal of Investigative Dermatology·Fen ShiBing Tang
May 4, 2018·Scientific Reports·Evan F GarnerElizabeth A Beierle
Dec 7, 2018·Neurology India·Paola Caruso, Rita Moretti
Dec 13, 2019·Pediatric Hematology and Oncology·Alexandre S PerlaRafael Roesler
Oct 9, 2013·Oncology Reports·Li ZhangYuan Zhou
Sep 20, 2017·Journal of Neuropathology and Experimental Neurology·Ricarda HannenJoerg Walter Bartsch
Aug 21, 2019·Frontiers in Pharmacology·Sara GrassiPaola Giussani
Apr 25, 2019·Cancers·Sascha MarxBernhard H Rauch
Jan 31, 2020·Frontiers in Immunology·Esther Melamed, Michael William Lee
May 23, 2018·Oxidative Medicine and Cellular Longevity·Teruaki TakasakiReiko Sugiura
Aug 13, 2017·The Biochemical Journal·Matthias DedobbeleerBernard Rogister
May 20, 2021·Drug Design, Development and Therapy·Marzia FronzaEleonora Cocco
Jul 3, 2021·International Journal of Molecular Sciences·Rosaria BassiPaola Giussani
Jul 25, 2021·International Journal of Molecular Sciences·Naoya HirataYasunari Kanda

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