Induction of burst suppression or coma using intravenous anesthetics in refractory status epilepticus

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Bong Su KangSang Kun Lee

Abstract

General anesthetic-induced coma therapy has been recommended for the treatment of refractory status epilepticus (RSE). However, the influence of electroencephalographic (EEG) burst suppression (BS) on outcomes still remains unclear. This study investigated the impact of intravenous anesthetic-induced BS on the prognosis of RSE using a retrospective analysis of all consecutive adult patients who received intravenous anesthetic treatment for RSE at the Seoul National University Hospital between January 2006 and June 2011. Twenty-two of the 111 episodes of RSE were enrolled in this study. Of the 22 RSE patients, 12 (54.5%) were women and 18 (81.4%) exhibited generalized convulsive status epilepticus. Sixteen patients (72.7%) were classified as having acute symptomatic etiology, including three patients with anoxic encephalopathy, and others with remote symptomatic etiology. Only two patients (9.1%) had a favorable Status Epilepticus Severity Score (0-2) at admission. All patients received midazolam (MDZ) as a primary intravenous anesthetic drug for RSE treatment; three (13.6%) received MDZ and propofol, and one (4.5%) received MDZ and pentobarbital. The rates of mortality and poor outcome at discharge were 13.6% (n=3) and 54.5% (n...Continue Reading

References

Jan 1, 1994·Epilepsia·A R TowneR J DeLorenzo
Aug 1, 1993·Annals of Emergency Medicine·A Jagoda, S Riggio
Jan 23, 1999·Clinical Therapeutics·D F Hanley, J F Kross
Feb 21, 2006·Lancet Neurology·James W Y Chen, Claude G Wasterlain
Jun 14, 2006·Neurology·Andrea O RossettiEdward B Bromfield
Jan 7, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H MeierkordUNKNOWN European Federation of Neurological Societies
Sep 30, 2010·Neurocritical Care·Andrea O RossettiJong Woo Lee
Apr 25, 2012·Neurocritical Care·Gretchen M BrophyUNKNOWN Neurocritical Care Society Status Epilepticus Guideline Writing Committee
Jan 16, 2013·JAMA Neurology·Sara E HockerAlejandro A Rabinstein

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Citations

Aug 9, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Robert C TaskerUNKNOWN Pediatric Status Epilepticus Research Group
Oct 10, 2018·Frontiers in Human Neuroscience·Antonia FleischmannMatthias Kreuzer
Apr 9, 2019·Epilepsia·Wolfgang G MuhlhoferJerzy P Szaflarski
Jul 14, 2016·Neurocritical Care·Emily L JohnsonEva K Ritzl
Apr 24, 2018·BMC Neurology·Kanitpong PhabphalAlan Geater
Jul 3, 2020·Acta Neurologica Scandinavica·Edoardo CaronnaEstevo Santamarina
Jul 3, 2018·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Dheeraj MasapuG S Umamaheswara Rao
Apr 22, 2020·Seizure : the Journal of the British Epilepsy Association·Sahar FarhatAhmad Beydoun
Jun 2, 2020·Seizure : the Journal of the British Epilepsy Association·Yusuke IshidaHiroaki Nagase
Aug 31, 2020·Seizure : the Journal of the British Epilepsy Association·Mahsa SadeghiRohit Marawar

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