Induction of c-Fos and DeltaFosB immunoreactivity in rat brain by Vagal nerve stimulation.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
J Thomas CunninghamAlan Frazer

Abstract

Vagus nerve stimulation (VNS) is used as therapy for treatment-resistant depression or epilepsy. This study used immunohistochemistry for biomarkers of short-term (c-Fos) and long-term (DeltaFosB) neuronal activation to map regions in brain that are activated by acute (2 h) or chronic (3 weeks) VNS in conscious Sprague-Dawley rats. Electrodes (Cyberonics Inc.) were implanted on the left vagus nerve and 1 week after surgery, stimulation began using parameters employed clinically (one burst of 20 Hz, 250 micros pulse width, 0.25 mA stimulation for 30 s every 5 min). Radio telemetry transmitters were used for monitoring blood pressure, heart rate, activity, and respiratory rate during VNS; neither acute nor chronic VNS significantly affected these parameters. Acute VNS significantly increased c-Fos staining in the nucleus of the solitary tract, paraventricular nucleus of the hypothalamus, parabrachial nucleus, ventral bed nucleus of the stria terminalis, and locus coeruleus but not in the cingulate cortex or dorsal raphe nucleus (DRN). Acute VNS did not affect DeltaFosB staining in any region. Chronic VNS significantly increased DeltaFosB and c-Fos staining bilaterally in each region affected by acute VNS as well as in the cingula...Continue Reading

References

Jan 1, 1990·Epilepsia·D M Woodbury, J W Woodbury
Sep 1, 1989·Journal of Neuroscience Methods·M Dragunow, R Faull
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Nov 1, 1982·The Journal of Comparative Neurology·M Kalia, J M Sullivan
Apr 8, 1995·Journal of the Autonomic Nervous System·C R AndersonA I Smith
Mar 1, 1995·Journal of Neurobiology·T Curran, J I Morgan
Apr 1, 1997·Synapse·S MorinobuR S Duman
Dec 5, 1998·Neurochemistry International·K J Kovács
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R J GrindstaffJ T Cunningham
Feb 7, 2001·The American Journal of Psychiatry·M S NoblerJ J Mann
Oct 5, 2001·Expert Opinion on Pharmacotherapy·P J GoodnickH A Sackeim
May 15, 2002·Trends in Pharmacological Sciences·John F CryanIrwin Lucki
Jan 29, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Anna BarnesDavid Wyper
Feb 6, 2004·Progress in Neurobiology·R A L Dampney, J Horiuchi
Mar 9, 2004·Journal of Psychiatric Research·Scott E KrahlAlbert Sattin
Apr 15, 2004·Experimental Neurology·B Matthew HoweJ Thomas Cunningham
Oct 2, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lisa L JiJ Thomas Cunningham
Oct 7, 2004·Neuropharmacology·Eric J Nestler
Mar 8, 2005·Neuron·Helen S MaybergSidney H Kennedy

❮ Previous
Next ❯

Citations

Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Paul BoonKristl Vonck
Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew H MilbyGordon H Baltuch
Jan 31, 2012·The Journal of Pharmacology and Experimental Therapeutics·Havan FurmagaAlan Frazer
Mar 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hui YuZhe-Yu Chen
Sep 8, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Fuzhan ParhizgarRishi Raj
Jan 24, 2012·European Journal of Gastroenterology & Hepatology·David J Levinthal, Klaus Bielefeldt
Jan 23, 2016·Biological Psychiatry·Flavia R Carreno, Alan Frazer
Jun 28, 2015·Neuroscience and Biobehavioral Reviews·Annelies GrimonprezKristl Vonck
Nov 20, 2012·Psychoneuroendocrinology·K V ThrivikramanMichael J Owens
Oct 2, 2012·Journal of Chemical Neuroanatomy·K RijkersG Hoogland
May 14, 2011·Experimental Neurology·Marlien AalbersKim Rijkers
Aug 21, 2010·Epilepsy & Behavior : E&B·Kristl VonckPaul Boon
Sep 26, 2009·Epilepsy & Behavior : E&B·Steven C SchachterUNKNOWN Summit Contributors
Aug 12, 2009·Neuroscience and Biobehavioral Reviews·Peter DomeZoltan Rihmer
Apr 29, 2009·Experimental Neurology·A John Rush, Susan E Siefert
Mar 22, 2015·Journal of Voice : Official Journal of the Voice Foundation·Kristiane Van LierdeKristl Vonck
Oct 30, 2015·International Journal of Neural Systems·Annelies GrimonprezKristl Vonck
May 4, 2011·The European Journal of Neuroscience·Francesco FornaiAntonio Paparelli
Dec 10, 2015·Pain·Shih-Pin ChenCenk Ayata
Sep 15, 2015·Headache·Hsiangkuo Yuan, Stephen D Silberstein
Nov 25, 2014·CNS Neuroscience & Therapeutics·Jian Xu, Hong Lei
Sep 6, 2014·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Aparna ShahAlan Frazer
Sep 4, 2012·Behavioural Brain Research·Xu ZhangYing Li
Dec 9, 2017·Journal of Neural Engineering·Jesse P SomannPedro P Irazoqui
Jul 27, 2017·Journal of Neural Engineering·Simon C CorkChristofer Toumazou
Jul 4, 2018·Cephalalgia : an International Journal of Headache·Marta Vila-PueyoSimon Akerman
Oct 30, 2018·Pain·Marta Vila-PueyoPhilip R Holland
Oct 21, 2011·Nature Reviews. Neuroscience·Paul J Kenny
Jan 27, 2012·Rinshō shinkeigaku = Clinical neurology·Kensuke KawaiNobuhito Saito
May 10, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Eric BeaumontNathan Cantrell
Oct 5, 2019·Scientific Reports·Karen-Anne McVey NeufeldPaul Forsythe
Jul 2, 2019·Experimental and Therapeutic Medicine·Yan Wang, Zhiping Li
Jun 7, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Flavia R Carreno, Alan Frazer
Nov 1, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Laureen D HachemGeorge M Ibrahim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.