Induction of c-fos by an anti-epidermal growth factor receptor monoclonal antibody

Biochemical and Biophysical Research Communications
R TaetleC MacLeod

Abstract

The effect of epidermal growth factor (EGF) or a monoclonal antibody to the human EGF receptor on c-fos and c-myc gene expression was examined in KB epidermoid carcinoma cells. EGF increased c-fos transcripts within 30 min and c-myc transcripts within 6-24 hours. The antibody transiently increased c-fos expression within 30 minutes, but did not alter expression of c-myc. Cycloheximide potentiated the c-fos induction by both EGF and antibody. C-fos induction by antibody was less consistent, and was of briefer duration and lesser intensity than the induction by EGF. Nuclear transcription of c-fos decreased in cells treated with EGF or antibody, indicating that c-fos induction by EGF or antibody resulted from post-transcriptional mechanisms.

References

Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H SunadaC L MacLeod
Aug 7, 1986·Nature·J I Morgan, T Curran
Apr 1, 1988·Molecular and Cellular Biology·K T RiabowolJ R Feramisco
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T KawamotoJ Mendelsohn

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Citations

Jan 1, 1990·Journal of Neuroscience Research·B RogisterG Moonen

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