PMID: 2106445Mar 1, 1990Paper

Induction of c-fos mRNA and protein in neurons and glia after traumatic brain injury: pharmacological characterization

Experimental Neurology
M DragunowR Frith

Abstract

Focal brain injury in mice induced c-fos mRNA and protein in neurons throughout the damaged neocortex, including the piriform and the entorhinal cortices, as well as in nonneural brain cells (e.g., glia, pia, ependyma). The pattern of c-fos induction after injury suggested that injury led to spreading depression which then led to c-fos induction in neurons. Human neurons in the temporal cortex and hippocampus also showed c-fos protein induction after neurosurgical trauma. The c-fos mRNA and protein induction in mouse neurons was prevented by the noncompetitive NMDA antagonist ketamine but only partially inhibited by the voltage-dependent calcium channel antagonist nifedipine and the calmodulin antagonist trifluoperazine. The c-fos protein induction in nonneural brain cells after injury was not affected by these drugs. Thus, induction of c-fos in neocortical neurons after focal brain injury is partly NMDA receptor mediated.

Citations

Jan 1, 1991·Molecular Neurobiology·W C AbrahamW P Tate
Nov 26, 1990·Brain Research·I HozumiW T Norton
Aug 28, 1995·Brain Research·B WoodsideS Amir
Nov 1, 1993·Journal of the Neurological Sciences·D Leifer, N W Kowall
Jul 1, 1995·Brain Research. Brain Research Reviews·M Dragunow, K Preston
Jul 1, 1995·Brain Research. Brain Research Reviews·M Glass, M Dragunow
Mar 1, 1993·Brain Research. Molecular Brain Research·J DemmerW P Tate
Jan 1, 1995·Brain Research. Molecular Brain Research·J HonkaniemiF R Sharp
Aug 1, 1994·Brain Research. Molecular Brain Research·T YuguchiT Hayakawa
Oct 1, 1994·Neurochemistry International·D F CondorelliA M Giuffrida-Stella
Oct 24, 1994·Neuroscience Letters·U AdénB B Fredholm
Apr 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M Dragunow, P Hughes
Mar 3, 2004·Journal of the American College of Surgeons·Davida A RobinsonKenneth G Warner
Dec 1, 1995·Experimental Eye Research·T HaradaK Yoshida
Aug 18, 1997·Brain Research. Developmental Brain Research·M Natarajan, M Wilkinson
Oct 1, 1996·Progress in Neurobiology·D G Herrera, H A Robertson
Jun 14, 2000·Progress in Neurobiology·M P RathboneF Caciagli

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