PMID: 9178036Apr 1, 1997Paper

Induction of c-fos mRNA by lead in PC 12 cells

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
K KimJ P Bressler

Abstract

Addition of lead acetate to PC 12 pheochromocytoma cells elicits induction of c-fos, an immediate early response gene. Induction of c-fos was concentration- and time-dependent: the lowest concentration of lead acetate tested that induced c-fos was 10 microM; induction was observed after a 30 min incubation and remained high after 90 min. Treatment with lead acetate and cycloheximide superinduced c-fos mRNA. Actinomycin D, an inhibitor of mRNA transcription, decreased the level of c-fos mRNA induced by lead acetate by almost 80%. Cadmium chloride and zinc chloride did not induce c-fos mRNA. Since the c-fos gene encodes a transcription factor, Pb2+ has the potential to deregulate the expression of other genes.

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Citations

May 10, 2000·Toxicology Letters·A L JadhavP G Gunasekar
Nov 26, 2008·Toxicology Letters·B Kiran KumarRajanna Bettaiya
Jun 28, 2005·Archives of Environmental Contamination and Toxicology·Nukhet Aykin-BurnsNuran Ercal
May 7, 1999·Environmental Health Perspectives·J W BigbeeJ L Dupree
Sep 12, 2018·Toxics·Todd LeffRuta Jog
Jul 1, 1999·Journal of Neurochemistry·T ChakrabortiJ P Bressler
Dec 31, 1998·Current Opinion in Neurology·M V Johnston, G W Goldstein
Aug 15, 2001·American Journal of Physiology. Cell Physiology·L OliviJ Bressler
Oct 2, 2001·Toxicology and Applied Pharmacology·C M BoutonJ Pevsner

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