PMID: 8971809Nov 29, 1996Paper

Induction of c-Jun immunoreactivity in spinal cord and brainstem neurons in a transgenic mouse model for amyotrophic lateral sclerosis

Neuroscience Letters
D JaarsmaV J de Jong

Abstract

Transgenic mice carrying amyotrophic lateral sclerosis (ALS)-linked superoxide dismutase 1 (SOD1) mutations develop a motoneuron disease resembling human ALS. c-Jun is a transcription factor frequently induced in injured neurons. In this study we have examined the distribution of c-Jun-immunoreactivity in the brainstem and spinal cord of transgenic SOD1 mice with a glycine 93 alanine (G93A) mutation. In non-transgenic littermates c-Jun immunostaining was predominantly situated in motoneurons. The number of c-Jun immunoreactive motoneuron was reduced in SOD1(G93A) mice due to pronounced loss of motoneurons. In SOD1(G93A) mice, however, c-Jun-immunoreactivity was strongly induced in neurons in the intermediate zone (Rexed's laminae V-VIII and X) of the spinal cord and throughout the brainstem reticular formation. These findings are of interest since increased levels of c-jun also have been found in the intermediate zone of the spinal cord of ALS patients. This c-Jun may be involved in the neurodegenerative processes both in ALS and in motoneuron disease in SOD1(G93A) mice.

References

Jan 1, 1992·Progress in Neurobiology·E Jankowska
Dec 1, 1987·Neuroscience·J C Holstege, H G Kuypers
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·M E RippsJ W Gordon
Jul 1, 1995·Brain Research. Brain Research Reviews·M Dragunow, K Preston

❮ Previous
Next ❯

Citations

Jan 7, 2000·Biochemical and Biophysical Research Communications·V N TrieuF M Uckun
Jun 20, 1998·Neuropathology and Applied Neurobiology·E M Fisher
Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eran PerlsonErika L F Holzbaur
Mar 13, 2003·Clinical Genetics·D Majoor-KrakauerA Hofman
Jun 1, 2011·Neurobiology of Disease·Ciro IaccarinoClaudia Crosio
Jul 1, 1997·Reviews in the Neurosciences·M DragunowR L Faull
Aug 18, 2017·Science Translational Medicine·Claire E Le PichonJoseph W Lewcock

❮ Previous
Next ❯

Related Concepts

Related Feeds

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating genetic alterations in this genetically heterogeneous disorder.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.