Induction of calcitonin gene-related peptide-like immunoreactivity in hippocampal neurons following ischemia: a putative regional modulator of the CNS injury/immune response

Experimental Neurology
K BullochB S McEwen

Abstract

Calcitonin gene-related peptide (CGRP) is a potent vasodilator and immune cell modulator. In two studies within the hippocampal formation (HF), CGRP-like immunoreactivity (CGRP-LI) was increased in the inner molecular layer of the dentate gyrus after adrenalectomy and in mossy cells after colchicine-induced destruction of granule neurons. Given the increase in CGRP-LI following damage to the granule cell region of the HF, we investigated another trauma model, ischemia, that targeted different areas of the HF, CA1 region, and subiculum to ascertain the regional expression of this peptide after insult. Following ischemia, light microscopic evaluation showed CGRP-LI in basket cell-like neuronal perikarya within the dorsal subiculum and CA1 region of the hippocampus and in varicose fibers within the CA2 region of the hippocampus. Control rats rarely expressed CGRP-LI within neurons in these regions. In ischemic brains, double-labeled immunocytochemistry with antibodies to various neural markers demonstrated co-localization of CGRP-LI primarily within surviving subicular and CA1 cells resembling interneurons containing parvalbumin-LI or calbindin-LI. Electron microscopic analysis of the CA1 region from ischemic brains showed that CG...Continue Reading

References

Jan 1, 1992·Canadian Journal of Physiology and Pharmacology·R A Swanson
Jan 1, 1991·Neuroscience·R Schmidt-Kastner, T F Freund
Feb 1, 1995·Stroke; a Journal of Cerebral Circulation·J ZhangC A Piantadosi
May 1, 1993·The Journal of Comparative Neurology·J G ValtschanoffH H Schmidt
Oct 1, 1993·Current Opinion in Neurobiology·E Gould, B S McEwen
May 1, 1996·Baillière's Clinical Rheumatology·I BercziR J Warrington

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Citations

Mar 25, 2006·Nature Reviews. Immunology·Esther M Sternberg
Apr 17, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Helen E Scharfman
Aug 8, 2015·Scientific Reports·Narumi Hashikawa-HobaraNaoya Hashikawa
Dec 21, 2016·The Journal of Experimental Medicine·Sachin P GadaniJonathan Kipnis
Jun 27, 2018·The American Journal of Tropical Medicine and Hygiene·Oscar H Del BruttoMark J Sedler
Jul 23, 2019·Headache·Jonathan M Borkum
Aug 28, 2020·Stress : the International Journal on the Biology of Stress·Firdaus S DhabharRobert L Spencer
Mar 28, 2021·Scientific Reports·Narumi Hashikawa-HobaraNaoya Hashikawa

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