PMID: 9160097May 1, 1997Paper

Induction of CD8+ CTL recognizing mycobacterial peptides

Scandinavian Journal of Immunology
H M VordermeierD P Harris

Abstract

Mycobacterium tuberculosis is the single, most important cause of morbidity attributable to a single infectious organism. CD8+ T cells play an important role in anti-tuberculous immune responses in both mice and humans. Data concerning the identity of mycobacterial antigens recognized by CD8+ T cells is limited; consequently, few CTL epitopes have been characterized. The authors identified allele-specific (H-2b and d) MHC class I binding motifs in six prominent M. tuberculosis protein antigens (the 19 and 38 kDa lipoglycoproteins and the 10, 16, 65 and 70 kDa stress proteins). These predicted epitopes were tested for MHC binding as well as their ability to elicit peptide-specific CTL following in vivo priming. The authors were able to identify eight previously undescribed mycobacterial CTL epitopes by using spleen cells from peptide-immunized mice. In addition, CTL specific for at least one of these epitopes also recognized the naturally processed epitope presented on transfected EL4 target cells. These mycobacteria-derived CTL epitopes could be important for future analysis of the involvement of CD8+ T cells in M. tuberculosis infection, pathogenesis and vaccine development.

Citations

Apr 1, 2008·Journal of Biosciences·Angelo Martino
Apr 1, 2000·Microbes and Infection·W P Maksymowych, K P Kane
Feb 28, 2001·Microbiology and Immunology·I SugawaraY Iwakura
Nov 1, 2006·Critical Reviews in Immunology·Joshua S M Woodworth, Samuel M Behar
Aug 18, 2000·Immunology and Cell Biology·S M Smith, H M Dockrell
Nov 26, 2003·Critical Reviews in Microbiology·Himanshu KumarR N K Bamezai
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·O NeyrollesD Young
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marta RomanoKris Huygen

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