PMID: 8964611Jan 1, 1996Paper

Induction of cell death via Fas (CD95, Apo-1) may be associated with but is not dependent on Fas-induced tyrosine phosphorylation

Immunology Letters
O JanssenD Kabelitz

Abstract

Cross-linking of the Fas-antigen (CD95, Apo-1) triggers apoptosis in activated T cells and transformed T cell lines. Fas-induced apoptosis has been previously reported to require Fas-triggered tyrosine phosphorylation of various proteins. In the present study, we have compared the protein tyrosine phosphorylation pattern and the apoptosis sensitivity in a set of Jurkat variants selected for the absence or presence of T cell receptor (TCR)/CD3 expression and resistance or sensitivity to Fas-mediated apoptosis. While tyrosine phosphorylation upon Fas-ligation was readily apparent in wild-type Jurkat cells (which are sensitive to anti-Fas-induced apoptosis), drastically reduced tyrosine phosphorylation was observed in Fas-resistant Jurkat subclones (which still express CD95 on their surface). More importantly, TCR/CD3-negative Jurkat variants which expressed normal levels of CD95 and were fully susceptible to Fas-triggered cell death, did not show any protein tyrosine phosphorylation upon Fas-ligation. Taken together, our data demonstrate that Fas-induced cell death can be associated with but is not dependent on protein tyrosine phosphorylation.

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Citations

May 5, 2001·Pharmacology & Therapeutics·K SharmaY F Shi
Aug 5, 2000·Journal of Reproductive Immunology·T Tanaka, N Umesaki
May 31, 2012·The Journal of Biological Chemistry·Isabell LangHarald Wajant
Oct 6, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·T TanakaS Ogita
Aug 4, 2004·The Journal of Cell Biology·Sebastian KreuzHarald Wajant
Jun 1, 1997·European Journal of Immunology·M C Ruiz-RuizA López-Rivas
Jan 24, 2006·International Journal of Immunogenetics·H KudatO Guven
May 21, 2010·Drug Metabolism Reviews·Zdenek Dvorak, Peotr Pavek
Jan 16, 1999·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·O PelkonenH Raunio
Jan 4, 2001·Drug Metabolism Reviews·S A WrightonP B Watkins
Aug 1, 2006·Drug Metabolism Reviews·Lesley A StanleyC Roland Wolf
Jan 22, 2013·Drug Metabolism Reviews·Sabine Gerbal-ChaloinMartine Daujat-Chavanieu

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