PMID: 9436036Jan 22, 1998Paper

Induction of cell differentiation and programmed cell death in amphibian metamorphosis

Human Cell
A Nishikawa

Abstract

Both the phenomena, the cell growth and differentiation, and the programmed cell death, are involved in the reconstruction of body from larval type to adult type during amphibian metamorphosis. Since all of metamorphic events are triggered by increase of plasma thyroid hormone level, the reconstruction of body during metamorphosis will provide useful biological system for analyzing the mechanism of hormonal induction of cell differentiation and programmed cell death. Induction of death of skein-type epidermal basal cells in tail skin of bullfrog tadpoles was involved in cell cycle arrest caused by triiodothyronine (T3). On the other hand, induction of adult type stratified and cornified epidermis was involved in T3-induction of the growth and differentiation of non-skein type epidermal basal cells in body skin. Developmental origin of these two different basal cells should be clarified. Analysis of adult type epidermal keratin expression during Xenopus metamorphosis revealed that enhanced transcription of adult type gene by synergism between T3 and glucocorticoid. Since receptors of these two hormones are belong to the same members of steroid receptor super family, interaction of hormones and hormone receptors should be studied...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.