Induction of central tolerance by the factor Aire: molecular and epigenetic regulation

Médecine sciences : M/S
Noëlla LopesMagali Irla

Abstract

The establishment of thymic central tolerance is a critical process to prevent the development of autoimmune diseases. Medullary thymic epithelial cells (mTEC) are essential to this process through the expression of the transcription factor Aire, which controls the transcription of many genes encoding tissue-restricted antigens. Mutations in the Aire gene are responsible for a rare autoimmune disorder called APECED (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy). This review summarizes our current knowledge on the mode of action of Aire at the molecular and epigenetic levels in controlling the expression of tissue-restricted antigens. We also discuss recently described additional roles of this transcription factor in the induction of central T-cell tolerance.

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Citations

Feb 28, 2017·Médecine sciences : M/S·Nadine DraginSonia Berrih-Aknin
Mar 25, 2016·Médecine sciences : M/S·Johan ArnoldFrédéric Gros
Sep 26, 2017·Médecine sciences : M/S·Vincent GiesAnne-Sophie Korganow

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