PMID: 6493272Oct 1, 1984Paper

Induction of chromosome aberrations and sister-chromatid exchanges in CHO-K1 cells by o-phenylphenol

Mutation Research
S Tayama-NawaiK Hiraga

Abstract

o-Phenylphenol (OPP), is used in Japan as a fungicide in food additives for citrus fruits. The induction of chromosome aberrations and sister-chromatid exchanges (SCEs) by OPP in cultured Chinese hamster ovary (CHO-K1) cells was studied. Cells were exposed to various concentrations of OPP ranging from 50 to 175 micrograms/ml for 3 h, and further incubated for 27 and 42 h. These incubation periods are almost equal to 2 and 3 cell cycles. SCEs and chromosome aberrations were induced by OPP at concentrations of 100, 125 and 150 micrograms/ml after the incubation for 27 h. For chromosome aberrations, chromatid breaks and exchanges there was a dose-dependent increase. Diplochromosomes due to endoreduplication were also caused by the same concentrations of OPP in a dose-dependent manner. After incubation for 42 h, chromosome aberrations were also increased by OPP at concentrations of 100 and 125 micrograms/ml, but the frequencies of SCEs were not significantly different from those of the control. These results suggest that OPP has a cytogenetic toxicity, and that the DNA damage resulting in SCEs induced by OPP is relatively short-lived and can be repaired during the longer incubation time.

References

Nov 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K Hiraga, T Fujii
Jan 1, 1983·Chemico-biological Interactions·R H ReitzP G Watanabe

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Citations

Feb 17, 2005·Environmental and Molecular Mutagenesis·David Brusick
May 1, 1989·Mutation Research·S TayamaY Nakagawa
Oct 24, 2001·Mutation Research·S Tayama, Y Nakagawa
Dec 19, 2002·Critical Reviews in Toxicology·E M BomhardM Richter
Oct 5, 2007·Mutation Research·Sumiko TayamaKuniaki Tayama
Jan 1, 1990·Chemico-biological Interactions·F NagaiI Kano
Apr 20, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Balakrishnan, D A Eastmond
Aug 28, 2019·Environmental and Molecular Mutagenesis·Lei-Lei YangShen Yin

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