PMID: 7512690Apr 1, 1994Paper

Induction of chromosome aberrations by pyrimethamine in cultured Chinese hamster (CHL) cells

Mutation Research
T OnoH Yoshimura

Abstract

Induction of chromosome aberrations was investigated in cultured Chinese hamster cells treated with pyrimethamine. Pyrimethamine without metabolic activation strongly induced structural chromosome aberrations in a dose-dependent manner. Aberrant metaphase cells occurred at a frequency of 80%, when cells were treated at 1.6 microgram/ml for 48 h.

References

May 1, 1991·Mutation Research·I SbranaN Loprieno
Jan 1, 1985·Teratogenesis, Carcinogenesis, and Mutagenesis·A M TangapregassomC Petter
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J C Li, E Kaminskas
Jan 1, 1980·Mutation Research·T OhtaY Shirasu

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Citations

Feb 19, 2000·Teratogenesis, Carcinogenesis, and Mutagenesis·K K Vijayalaxmi, M Vishalakshi
Sep 5, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·Ciĝdem EgelNilüfer Aydemir
Oct 24, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·B TuncaR Bilaloglu
Feb 3, 2005·Cell Biology and Toxicology·A Abou-Eisha, M Afifi
Sep 1, 1997·Environmental Toxicology and Pharmacology·T OnoT Ohta

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