PMID: 7526183Dec 1, 1994Paper

Induction of chromosome aberrations in Syrian hamster renal cortical cells by various estrogens

Mutation Research
S K BanerjeeJ J Li

Abstract

Estrogens, both natural and synthetic, have been implicated in carcinogenesis at different organ sites in a variety of animals, including man, for more than six decades. However, the molecular mechanism(s) involved in the carcinogenic action of estrogens still remains both controversial and elusive. Cytogenetic damage in the hamster kidney has been studied after in vivo treatment with either potent or weak estrogens for varying periods. Compared to age-matched untreated control, diethylstilbestrol (DES) treatment resulted in significant increases in the number of chromatid gaps and breaks, chromosome breaks, and endoreduplicated cells in hamster renal cortical cells. These chromosomal aberrations (CA) were cumulative with continued hormone exposure from 1.0 to 5.0 months. However, chromosome exchanges as a result of the breaks were not elevated. After 5.0 months of hormone treatment, potent estrogens such as 17 beta-estradiol and Moxestrol exhibited similar frequencies of CA in the hamster kidney to that found for DES, whereas weak estrogens such as 17 alpha-estradiol and beta-dienestrol exhibited CA frequencies that were not significantly different from untreated levels. Ethinylestradiol treatment for a similar period resulted...Continue Reading

References

Jun 1, 1975·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A Llombart-Bosch, A Peydro
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A R Kinsella, M Radman
May 1, 1978·Mutation Research·M Sawada, M Ishidate
Jan 1, 1989·Teratogenesis, Carcinogenesis, and Mutagenesis·K Hillbertz-Nilsson, J G Forsberg
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T D OberleyJ J Li
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R T SchimkeR N Johnston
Jan 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·A H YangT D Oberley
Feb 1, 1982·Mutation Research·B HusumE Niebuhr
May 1, 1981·Mutation Research·C DrevonR Montesano

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Citations

Mar 5, 1999·Mutation Research·D Roy, J G Liehr
Dec 11, 2002·Theriogenology·A R C L BekerM M Bevers
Dec 23, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Paul E Goss, Kathrin Strasser-Weippl
Dec 7, 2007·Chemical Research in Toxicology·Judy L Bolton, Gregory R J Thatcher
Jul 11, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Deodutta RoySatya Narayan
Mar 9, 2004·Journal of Carcinogenesis·Kamaleshwar P Singh, Deodutta Roy
Jul 5, 2006·Environmental Health Perspectives·Katherine E LineySusan Jobling
Sep 17, 2004·International Journal of Radiation Biology·I R Radford
Sep 13, 2016·Chemical Research in Toxicology·Judy L Bolton, Tareisha Dunlap
Jun 5, 2004·Toxicology Letters·H F P JoostenE I Krajnc
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·D K SarkarK W Singletary
Mar 4, 2000·Endocrine Reviews·J G Liehr
Jul 19, 2011·Expert Review of Endocrinology & Metabolism·Jason L NellesGail S Prins
Aug 30, 2000·Journal of the National Cancer Institute. Monographs·E CavalieriD Roy
Feb 13, 2001·Regulatory Toxicology and Pharmacology : RTP·J G Liehr
Apr 1, 1997·Mutation Research·C B Klein, M Costa

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