PMID: 2492666Feb 1, 1989Paper

Induction of class I major histocompatibility complex antigen expression by West Nile virus on gamma interferon-refractory early murine trophoblast cells

Proceedings of the National Academy of Sciences of the United States of America
Nicholas J C KingA M Kesson

Abstract

Primary murine trophoblast giant cells (TGC) do not express detectable major histocompatibility complex (MHC) antigens and are refractory to the MHC-increasing effects of alpha and beta (virus-induced) interferons and gamma (immune type) interferon during early implantation (postcoital days 3.5-6). West Nile virus infection of primary TGC monolayers from postcoital-day-3.5 preimplantation blastocysts induced paternal MHC antigen expression within 16 hr, as detected by immunogold labeling for electron microscopy. Induction is unlikely to have been mediated by secreted virus-induced interferons or other factors, as it occurred in the presence of high concentrations of anti-alpha/beta interferon antibodies and was not induced by virus-inactivated supernatants from MHC-induced primary TGC cultures. Attempts to induce MHC antigen expression with poly(I.C) or recombinant tumor necrosis factor alpha in primary TGC cultures also failed. Thus, the apparent inhibition of MHC antigen expression in primary TGC during early implantation and their refractoriness to induction of de novo MHC antigen expression is not absolute. This may represent a maternal-and/or species-protective evolutionary device. As such, manipulation of this phenomenon ...Continue Reading

References

Jun 1, 1977·The Journal of Experimental Zoology·L M Wiley, R A Pedersen
Oct 1, 1977·The Journal of Experimental Medicine·C G WebbG M Edelman
Jul 1, 1975·The Journal of General Virology·W P Taylor, I D Marshall
Sep 1, 1977·Nature·M H Sellens
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K OzatoB M Orrison
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J SancéauC Vaquero
Jan 1, 1984·Differentiation; Research in Biological Diversity·D P BarlowD C Burke

❮ Previous
Next ❯

Citations

Aug 1, 1994·Vaccine·K Venugopal, E A Gould
Dec 6, 2006·Immunology and Cell Biology·Nicholas J C KingAlison M Kesson
May 20, 2003·Immunology and Cell Biology·Michael S Diamond
May 20, 2003·Immunology and Cell Biology·Mario LobigsMatthias Regner
May 20, 2003·Immunology and Cell Biology·Nicholas J C King, Alison M Kesson
Jun 26, 2002·Viral Immunology·Alison M KessonNicholas J C King
Aug 17, 2005·Journal of Virology·Robyn S KleinMichael S Diamond
Dec 15, 2005·Journal of Virology·Bimmi ShresthaMichael S Diamond
Nov 21, 2007·Médecine sciences : M/S·Doris G RansyHugo Soudeyns
Aug 21, 2013·Immunological Reviews·Daniel R GettsStephen D Miller
Dec 1, 1992·Differentiation; Research in Biological Diversity·W L DonaldsonD F Antczak
Oct 6, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chong WangMin Cui
Jul 1, 1989·American Journal of Reproductive Immunology : AJRI·J R Head
Nov 7, 2019·Viral Immunology·Branden R NelsonKristina M Adams Waldorf
Jun 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abi G AleyasSeong Kug Eo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.