Induction of class II major histocompatibility complex antigens in murine placenta by 5-azacytidine and interferon-gamma involves different cell populations.

European Journal of Immunology
I Athanassakis-VassiliadisJ Papamatheakis

Abstract

Class II MHC antigen expression is required for recognition of an alloantigen and generation of immune response. In rodents as well as in humans primary trophoblasts do not express class II MHC antigens. In this study we focused our interest on the mechanism(s) of class II antigen suppression on murine trophoblasts. First, we examined the possibility of gene inactivation by methylation and second the possibility of lymphokine regulation of the class II genes. The first possibility was tested by treatment of placental cells with 5-azacytidine (5-AzaC), a cytidine analog which upon incorporation into the DNA inhibits further methylation, thus leading to gene activation. In order to test the second possibility we treated placental cells with interferon-gamma (IFN-gamma) or interleukin 4 (IL4) which are known to induce class II antigen expression in many systems. We showed that treatment with 5-AzaC or IFN-gamma but not IL4 significantly increased class II expression on cytokeratin-positive and vimentin-negative adherent placental cells. Following placental cell fractionation we distinguished three cell subsets with different responsiveness to 5-AzaC and IFN-gamma. The first, characterized as placental macrophages, were induced to ...Continue Reading

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Citations

Jan 22, 2002·International Journal of Cancer. Journal International Du Cancer·Nienke van der StoepPeter J van den Elsen
Mar 1, 1992·Journal of Reproductive Immunology·I Athanassakis-VassiliadisJ Papamatheakis
Jun 1, 2000·Developmental and Comparative Immunology·I AthanassakisS Vassiliadis
May 4, 2001·Journal of Reproductive Immunology·I AthanassakisS Vassiliadis
Sep 20, 2001·International Immunopharmacology·I AthanassakisS Vassiliadis
Oct 14, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·I AthanassakisS Vassiliadis
Dec 1, 1992·British Journal of Haematology·S Vassiliadis, I Athanassakis
Nov 1, 1995·American Journal of Reproductive Immunology : AJRI·I AthanassakisS Vassiliadis
Aug 1, 1996·American Journal of Reproductive Immunology : AJRI·I AthanassakisS Vassiliadis
Jul 14, 2007·Seminars in Immunopathology·Gérard Chaouat
Jan 1, 1993·Journal of Receptor Research·I Athanassakis-VassiliadisS Vassiliadis
Mar 11, 1999·Journal of Receptor and Signal Transduction Research·I AthanassakisS Vassiliadis
Aug 12, 2000·The Journal of Experimental Medicine·R W Redline
Jun 1, 1997·American Journal of Reproductive Immunology : AJRI·B A CroyM van den Heuvel

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