Induction of classical and nonclassical MHC-I on mouse brain astrocytes by Japanese encephalitis virus

Virus Research
Sojan Abraham, Ramanathapuram Manjunath

Abstract

Infection with Flaviviruses upregulates the cell surface expression of MHC-I, MHC-II, ICAM-1 (CD54), VCAM-1 (CD106) and TAP proteins. Although all these studies have been confirmed using West Nile virus and other Flaviviruses, there are few reports that have examined the effects of Japanese encephalitis virus (JEV) infection directly on nonclassical and classical MHC expression in astrocytes. We show in this report that JEV infection of mouse brain astrocytes results in induction of the nonclassical MHC Class Ib genes, H-2T23, H-2Q4 and H-2T10 in addition to MHC-I, Type I (alpha/beta) IFNs, TAP-1, TAP-2, Tapasin, LMP-2, LMP-7 and LMP-10 but not IFNgamma, CD80, CD86 and MHC-II genes. The increased cell surface expression of these antigens as well as induction of the genes mentioned above as measured by RT-PCR suggests that JEV infection may lead to the induction of classical MHC Class Ia as well as nonclassical MHC Class Ib molecules.

References

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Citations

Mar 1, 2011·Neurochemistry International·Chun-Jung ChenChen-Jung Chang
Mar 4, 2008·Virus Research·Sojan AbrahamRamanathapuram Manjunath
Jan 20, 2007·Neurotoxicology and Teratology·Oksana O PolesskayaRobert F Smith
Dec 17, 2009·The Journal of General Virology·Chun-Jung ChenJian-Hong Chen
Jul 12, 2019·Frontiers in Microbiology·María-Angélica Calderón-PeláezJaime E Castellanos

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