PMID: 8917510Nov 12, 1996

Induction of cyclin D1 by simian virus 40 small tumor antigen

Proceedings of the National Academy of Sciences of the United States of America
G WatanabeRichard G Pestell


Cell-cycle progression is mediated by a co-ordinated interaction between cyclin-dependent kinases and their target proteins including the pRB and E2F/DP-1 complexes. Immunoneutralization and antisense experiments have established that the abundance of cyclin D1, a regulatory subunit of the cyclin-dependent kinases, may be rate-limiting for G1 phase progression of the cell cycle. Simian virus 40 (SV40) small tumor (t) antigen is capable of promoting G1 phase progression and augments substantially the efficiency of SV40 transformation through several distinct domains. In these studies, small t antigen stimulated cyclin D1 promoter activity 7-fold, primarily through an AP-1 binding site at -954 with additional contributions from a CRE site at -57. The cyclin D1 AP-1 and CRE sites were sufficient for activation by small t antigen when linked to an heterologous promoter. Point mutations of small t antigen between residues 97-103 that reduced PP2A binding were partially defective in the induction of the cyclin D1 promoter. These mutations also reduced activation of MEK1 and two distinct members of the mitogen-activated protein kinase family, the ERKs (extracellular signal regulated kinases) and the SAPKs (stress-activated protein kin...Continue Reading


Oct 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·P HenryS M Weissman
Oct 6, 1995·The Journal of Biological Chemistry·Chris AlbaneseRichard G Pestell
Jul 14, 1995·The Journal of Biological Chemistry·M Karin
Mar 30, 1995·Nature·R G QiuM Symons
May 15, 1995·Genes & Development·C J Sherr, J M Roberts
Jun 1, 1995·Genes & Development·R L BeijersbergenR Bernards
Jun 23, 1995·The Journal of Biological Chemistry·M Cobb, E J Goldsmith
Nov 18, 1994·Cell·C J Sherr
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·E A MusgroveR L Sutherland
Sep 1, 1994·Molecular and Cellular Biology·J A FrostJ R Feramisco
Apr 1, 1994·Molecular and Cellular Biology·C E DabrowskiP A Schaffer
May 12, 1994·Nature·John M KyriakisJ R Woodgett
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J WuT W Sturgill
Apr 1, 1993·Molecular and Cellular Biology·A S AlbertsJ R Feramisco
May 1, 1993·Genes & Development·V BaldinG Draetta
Sep 13, 1996·The Journal of Biological Chemistry·G WatanabeRichard G Pestell


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Jun 8, 2001·Biochemical and Biophysical Research Communications·R GilletV Joulin
Aug 24, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yarí E Marín, Suzie Chen
Jan 30, 2008·Archives of Toxicology·Masako MugurumaKunitoshi Mitsumori
Jan 25, 2008·Cancer Metastasis Reviews·Anna A Sablina, William C Hahn
Aug 7, 1998·Brain Research. Developmental Brain Research·G WatanabeRichard G Pestell
Mar 21, 2001·Cellular Signalling·E Sontag
Apr 20, 2001·Cytokine & Growth Factor Reviews·D JoyceRichard G Pestell
Dec 19, 2002·Cytokine & Growth Factor Reviews·Maofu FuRichard G Pestell
Oct 1, 2003·Respiratory Physiology & Neurobiology·Limei Zhou, M B Hershenson
Nov 22, 2005·Oncogene·Jason D Arroyo, William C Hahn
Apr 21, 2004·The Journal of Biological Chemistry·Anindita Kar-RoyShahid Jameel
Jul 23, 2009·Antioxidants & Redox Signaling·Michika MochizukiHiroshi Masutani
Sep 10, 2009·Antioxidants & Redox Signaling·Muyao Li, Naomi K Fukagawa
Feb 18, 2003·Molecular Biology of the Cell·Chris AlbaneseRichard G Pestell
Sep 21, 2007·Molecular Biology of the Cell·Miriam HuertaEsther López-Bayghen
May 22, 2003·Journal of the National Cancer Institute·Yu-Long HuRobert B Jaffe
Aug 5, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jennifer D CohenSerrine S Lau
Sep 5, 2001·Journal of Virology·O GjoerupT M Roberts
Mar 16, 2005·Journal of Virology·Tara M LoveB Schaffhausen
Sep 19, 2006·Molecular and Cellular Biology·Kongming WuRichard G Pestell
Oct 4, 2006·Molecular and Cellular Biology·Jinsong ZhuAlexander S Raikhel
Aug 15, 2003·Molecular and Cellular Biology·Chenguang WangRichard G Pestell
Oct 16, 2003·Molecular and Cellular Biology·Natasha RekhtmanArthur I Skoultchi
Nov 28, 2007·Annual Review of Pathology·M B HershensonJulian Solway
Aug 5, 2010·Molecular Cancer Therapeutics·Nagathihalli S NagarajNipun B Merchant
Jun 25, 1998·American Journal of Respiratory Cell and Molecular Biology·M RamakrishnanM B Hershenson
Jan 28, 1999·American Journal of Respiratory Cell and Molecular Biology·N L MusaM B Hershenson
Oct 6, 2000·American Journal of Respiratory Cell and Molecular Biology·K PageM B Hershenson
Aug 2, 2002·American Journal of Respiratory Cell and Molecular Biology·K PageM B Hershenson
Mar 13, 2001·Biochemical and Biophysical Research Communications·Y G ParkY S Cho-Chung
Feb 26, 2014·The Journal of Cell Biology·Emily SteedKarl Matter
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·B D GehmJ L Jameson
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·Frank BeierPhyllis LuValle
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·K T AkamaL J Van Eldik
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·S GaniatsasL I Zon
Feb 19, 2011·Cancer Research·Shahana MajidRajvir Dahiya
Nov 4, 2000·Expert Opinion on Investigational Drugs·S ManiRichard G Pestell
Jun 19, 2012·Clinical Epigenetics·Zhi-Yi GuoFang Yang
Jun 10, 2009·Seminars in Cancer Biology·Jingwei ChengB Schaffhausen
Jan 5, 2005·Experimental Neurology·William J FreedMary Ellen Truckenmiller
Aug 18, 2004·Cancer Letters·Antonio De Luca, Gaetano Iaquinto
Jun 29, 2005·Brain Research. Brain Research Reviews·Martyn K WhiteKamel Khalili
Aug 8, 2015·Experimental Eye Research·Irene Lee-RiveraAna María López-Colomé
Jul 7, 2011·Virus Research·Caroline KnoxEva-Rachele Pesce
Sep 4, 2010·Journal of Virological Methods·Mark E SeamoneDaniel A Muruve
Sep 6, 2002·Biochemical Pharmacology·James HulitRichard G Pestell
Aug 10, 1999·Experimental Cell Research·B WhalenJ M Lehman
Feb 6, 2007·Biochimica Et Biophysica Acta·John M Kyriakis
Feb 10, 2009·Virology·Paul G CantalupoJames M Pipas
Oct 16, 2007·Virology·Kelly M FahrbachK Rundell
Dec 25, 2002·Chemistry & Biology·Weiying LinDavid S Lawrence
Aug 3, 2016·Scientific Reports·Kazuya FukasawaEiichi Hinoi
Aug 29, 1998·The Journal of Biological Chemistry·P K VadivelooJ A Hamilton
Sep 25, 1999·The Journal of Biological Chemistry·S KitazawaS Maeda
Nov 21, 1998·Veterinary Pathology·K A Schafer
Sep 25, 2003·Journal of Cellular Biochemistry·Sheila Maria Brochado WinnischoferMari Cleide Sogayar
May 3, 2002·The Journal of Biological Chemistry·Meng-Min LiuP J Kushner
Nov 21, 2007·Journal of Cellular Physiology·Kamel KhaliliMahmut Safak
Aug 3, 2007·The Journal of Biological Chemistry·Romaine FernandoJay Wimalasena
Dec 23, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tonje S SteigedalAstrid Laegreid
Jul 27, 1999·The Journal of Biological Chemistry·K PageM B Hershenson
May 26, 2001·The Journal of Biological Chemistry·A L AllanJ LaMarre
Nov 24, 1999·The Journal of Biological Chemistry·Chris AlbaneseRichard G Pestell
Mar 7, 2003·The Journal of Biological Chemistry·Lucia CicchillittiFabio Martelli
May 5, 2004·The Journal of Biological Chemistry·Maofu FuRichard G Pestell
Jun 14, 2005·The Journal of Biological Chemistry·Maofu FuRichard G Pestell
Nov 20, 1998·Molecular and Cellular Biology·K P MullaneB Schaffhausen
Aug 26, 1998·Molecular and Cellular Biology·J R BrownM E Greenberg
Aug 28, 2004·Endocrinology·Maofu FuRichard G Pestell
Apr 6, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·K PageM B Hershenson
Apr 6, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·C P BauerfeldK Page
Apr 27, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chris AlbaneseRichard G Pestell
May 19, 2007·Cancer Research·Lin WangI Bernard Weinstein

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