Induction of CYP1A1 by GABA receptor ligands

Biochemical and Biophysical Research Communications
M D SadarT B Andersson

Abstract

The induction of CYP1A1 is mediated via the aromatic hydrocarbon (Ah) receptor. Studies from our laboratory show CYP1A1 induction by picrotoxin and phenobarbital which prompted us to examine if other ligands of the gamma-aminobutyric acid (GABA) receptor could also induce CYP1A1. Here we report the nuclear translocation of the Ah receptor and its DNA binding activity to radiolabeled double-stranded synthetic xenobiotic response elements (XREs) in nuclear extracts, increased accumulation of CYP1A1 mRNA, and alterations in intracellular calcium concentrations in cells exposed to GABA receptor ligands.

Citations

Sep 13, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael S DenisonBin Zhao
Feb 18, 2014·Journal of Applied Toxicology : JAT·S Badal, R Delgoda
Sep 19, 2002·Biochemical and Biophysical Research Communications·Quoc-Binh N'GuyenYves Barra
Sep 6, 2002·Chemico-biological Interactions·Michael S DenisonLaura Bonati
May 21, 1999·Biochemical and Biophysical Research Communications·A WestlindM Ingelman-Sundberg
Feb 11, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M E Hahn

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