Aug 1, 1991

Induction of cytochrome P-450-dependent monooxygenases by isoniazid in hamster liver, kidney and lung

Journal of the Formosan Medical Association = Taiwan Yi Zhi
T H Ueng, Y F Ueng

Abstract

The effects of isoniazid on liver, kidney, and lung monooxygenases were determined using hamsters administered 0.8% of the antituberculosis drug in drinking water. Binding of isoniazid to liver microsomal cytochrome P-450 induced a Type II difference spectrum and the spectral binding was enhanced in hamsters treated with isoniazid. The levels of cytochrome P-450, NADPH-cytochrome c reductase, and cytochrome b5 in the tissues microsomes from isoniazid-treated hamsters were similar to the respective levels in control animals. In the liver, treatment with isoniazid caused 5- and 3-fold induction of aniline hydroxylase and N-nitrosodimethylamine demethylase activities, respectively. The treatment was without effect on hepatic benzo(a)pyrene hydroxylase or 7-ethoxycoumarin O-deethylase activities. In the kidneys, isoniazid treatment caused 6-, 2-fold, and 42% increases in monooxygenase activities toward aniline, N-nitrosodimethylamine, and 7-ethoxycoumarin, respectively. However, the treatment caused a 15% decrease in renal benzo(a)pyrene hydroxylase activity. In the lungs, isoniazid caused a 69% increase in aniline hydroxylase and, in contrast, a 30% decrease in 7-ethoxycoumarin O-deethylase activities. The treatment had no signifi...Continue Reading

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Mentioned in this Paper

Aniline
Ethanol
Ethanol Measurement
Lung
Microsomes
Cytochrome P450
Benzopyrene Hydroxylase
Hepatic
Hamsters
Cross Reactions

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