Induction of cytochrome P-450 isozymes by mirex and chlordecone.

Journal of Biochemical Toxicology
M LewandowskiE Hodgson

Abstract

The effect of the insecticides, mirex and chordecone (Kepone), on the cytochrome P-450 monooxygenase system in C57BL/6N mouse liver microsomes was studied. Mice were treated intraperitoneally with low (6 mg/kg) and high (30 mg/kg) doses of mirex and chlordecone in corn oil for 2 days. For comparison, mice were also treated with either phenobarbital (PB) or 3-methylcholanthrene (3-MC). All treatments significantly increased the hepatic microsomal P-450 content over that of controls. Benzphetamine N-demethylase, ethoxyresorufin O-deethylase, benzo[a]pyrene hydroxylase, and acetanilide hydroxylase activities were also determined. Mirex and chlordecone resembled phenobarbital with respect to the induction of monooxygenase activities. Immunoquantitation with antibodies to purified P-450 IIB1 (Pb-induced P-450) and P-450 IA1 (3-MC-induced P-450) indicated that mirex and chlordecone induced P-450 IIB1 in a dose-dependent manner. The high dose of mirex also induced a small amount of a protein cross reacting with the antibody to IA1. The induction of this isozyme did not, however, contribute significantly to the monooxygenase activities measured.

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Citations

Dec 1, 1995·Toxicology Letters·E HodgsonP E Levi
Mar 1, 1996·Environmental Health Perspectives·E Hodgson, P E Levi
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·G L Plaa
Jul 14, 2016·Environmental Health : a Global Access Science Source·Vincent NedellecWilliam Dab
Aug 26, 2018·Environmental Science and Pollution Research International·Damien A DevaultSébastien Bristeau
Jun 1, 1991·Toxicology and Applied Pharmacology·S Teo, M Vore

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