PMID: 3928374Aug 15, 1985Paper

Induction of cytochrome P-450b,e-type isozymes by polychlorinated biphenyls in rat liver. Molecular cloning of induced mRNAs

European Journal of Biochemistry
B ScholteJ de Vries


We have studied the induction of cytochrome P-450b,e-type antigen and mRNA by phenobarbital, 4,4'-dichlorobiphenyl and 2,4,5,2',4',5'-hexachlorobiphenyl in male Wistar rat liver. Chronic treatment of rats with 4,4'-dichlorobiphenyl leads to a relatively slow, 20-fold increase in the cytochrome P-450b,e-type antigen level and to an equivalent increase in the concentration of the corresponding mRNA. Treatment of rats with phenobarbital or 2,4,5,2',4',5'-hexachlorobiphenyl results in a faster and more pronounced increase of cytochrome P-450b,e-type antigen and mRNA levels. Analysis of clones from cDNA banks showed that two types of sequences are induced by phenobarbital corresponding to cytochrome P-450b and cytochrome P-450e respectively. 2,4,5,2',4',5'-Hexachlorobiphenyl appears to induce primarily a cytochrome P-450b-type sequence. The implications of these results for the study of the mechanism of induction are discussed.


Jan 1, 1979·Cold Spring Harbor Symposia on Quantitative Biology·L A LoebD K Dube
Feb 28, 1978·Biochemical and Biophysical Research Communications·P J Fraker, J C Speck
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