PMID: 3928374Aug 15, 1985Paper

Induction of cytochrome P-450b,e-type isozymes by polychlorinated biphenyls in rat liver. Molecular cloning of induced mRNAs

European Journal of Biochemistry
B ScholteJ de Vries

Abstract

We have studied the induction of cytochrome P-450b,e-type antigen and mRNA by phenobarbital, 4,4'-dichlorobiphenyl and 2,4,5,2',4',5'-hexachlorobiphenyl in male Wistar rat liver. Chronic treatment of rats with 4,4'-dichlorobiphenyl leads to a relatively slow, 20-fold increase in the cytochrome P-450b,e-type antigen level and to an equivalent increase in the concentration of the corresponding mRNA. Treatment of rats with phenobarbital or 2,4,5,2',4',5'-hexachlorobiphenyl results in a faster and more pronounced increase of cytochrome P-450b,e-type antigen and mRNA levels. Analysis of clones from cDNA banks showed that two types of sequences are induced by phenobarbital corresponding to cytochrome P-450b and cytochrome P-450e respectively. 2,4,5,2',4',5'-Hexachlorobiphenyl appears to induce primarily a cytochrome P-450b-type sequence. The implications of these results for the study of the mechanism of induction are discussed.

References

Jan 1, 1979·Cold Spring Harbor Symposia on Quantitative Biology·L A LoebD K Dube
Feb 28, 1978·Biochemical and Biophysical Research Communications·P J Fraker, J C Speck
Jul 1, 1982·Analytical Biochemistry·M P Reinhart, D Malamud
Oct 25, 1980·Journal of Molecular Biology·F SangerB A Roe
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D DiMaioT Maniatis
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·Y MizukamiY Fujii-Kuriyama
Mar 15, 1984·Biochemical Pharmacology·D W NebertO Hankinson
Jul 1, 1984·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Y YamazoeR Kato
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A Rampersaud, F G Walz
Jul 30, 1981·Biochemical and Biophysical Research Communications·E Le ProvostJ P Leroux
Jan 1, 1983·British Journal of Clinical Pharmacology·E E Ohnhaus, H Studer
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·Y Fujii-KuriyamaM Muramatsu

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