PMID: 9169855May 15, 1997Paper

Induction of cytokine transcripts in the central nervous system and pituitary following peripheral administration of endotoxin to mice

Journal of Neuroscience Research
F PitossiH Besedovsky

Abstract

The regional distribution and inducibility of cytokines in the normal brain is still a matter of controversy. As an attempt to clarify this issue, we studied the constitutive and induced expression of interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma mRNAs in the brain, pituitary, and spleen of mice using qualitative and semiquantitative reverse-transcription polymerase chain reaction. The contribution of nonbrain cells to the cytokine transcripts detected was considered. With the exception of IFN-gamma mRNA, transcripts for the other cytokines were found to be constitutively present in the brain. Following i.p. injection of lipopolysaccharide (LPS) at a dose below those described to disrupt the blood-brain barrier (BBB), cytokine mRNA expression was increased in the spleen, the pituitary, and the brain. In the brain, the onset of transcription varied from 45 min (IL-1beta, TNF-alpha) to 4 hr (IFN-gamma), and the peak of mRNA accumulation was observed at different times depending on the cytokine and the brain region studied. IL-1 and IL-6 were highly expressed in the hypothalamus and hippocampus, while TNF-alpha expression was more marked in the thalamus-striatum. The cortex was the reg...Continue Reading

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Citations

Apr 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Claudio MastronardiMa-Li Wong
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May 28, 2008·Brain : a Journal of Neurology·María Clara Pott GodoyFernando Juan Pitossi
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