PMID: 9531966Apr 9, 1998Paper

Induction of cytokines and expression of surface receptors in Mono Mac 6 cells after infection with different Legionella species

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Birgid NeumeisterHinnak Northoff

Abstract

The ability of Legionella species to multiply within human mononuclear phagocytes is usually regarded as being associated with their pathogenicity. Activation of host cells results in inhibition of intracellular Legionella multiplication. The most effective substance to induce macrophage activation, both in vivo and in vitro, is interferon-gamma. In addition, some evidence exists that macrophage-derived cytokines may contribute to the host defense against L. pneumophila, but the production of pro- and antiinflammatory cytokines by monocytes after infection with different Legionella species has not been reported with regard to their ability to multiply within the host cells. We therefore examined the production of TNF-alpha, IL-1, IL-6, IL-8, IL-10 and TGF-beta by Mono Mac 6 cells after infection with Legionella species of different human prevalence that differ in their ability to replicate within this macrophage-like cell line. After infection, Mono Mac 6 cells showed a cytokine response with time kinetics characteristic for the cytokine. Maximum cytokine levels produced differed with Legionella species, but were not related to intracellular multiplication rates. Moreover, LPS-tolerant Mono Mac 6 cells, which failed to produce ...Continue Reading

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Citations

Feb 15, 2000·Journal of Bacteriology·A FliegerB Neumeister
Mar 14, 2001·American Journal of Respiratory Cell and Molecular Biology·K MatsunagaY Yamamoto
Feb 2, 2010·FEMS Microbiology Reviews·Frédéric Lamoth, Gilbert Greub
Mar 9, 2011·Infection and Immunity·Kessler McCoy-SimandleNicholas P Cianciotto
Apr 28, 2006·FEMS Microbiology Letters·Mongi AkermiSophie Jarraud

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