Induction of delayed hypersensitivity to alloantigens coinjected with Langerhans cells into the anterior chamber of the eye. Abrogation of anterior chamber-associated immune deviation

Transplantation
J S Williamson, J Wayne Streilein

Abstract

Inoculation of P815 tumor cells (DBA/2 origin) into the anterior chamber of eyes of BALB/c mice normally produces anterior chamber-associated immune deviation (ACAID) whereby delayed hypersensitivity (DH) responses to the minor H alloantigens of the tumor cells are suppressed. Based on our previous work showing an association of Langerhans cell infiltration into central cornea with the abrogation of ACAID, we have hypothesized that the induction of ACAID may depend upon the avoidance of local antigen processing within the anterior chamber. In this study, we have examined whether various putative antigen-presenting cells coinjected with allogeneic P815 cells into the anterior chamber could alter the course of the subsequent systemic alloimmune response. BALB/c recipients of intracameral P815 cells admixed with BALB/c spleen cells, B cells, or A20 B lymphoma cells developed ACAID. However, recipients of tumor cells admixed with cutaneous epidermal cells containing LC, and those receiving intracameral P815 cells admixed with purified LC developed vigorous DBA/2-specific delayed hypersensitivity responses. We conclude that avoidance of antigen processing and presentation by specialized APC such as dendritic LC within the anterior c...Continue Reading

Citations

Sep 18, 1997·Immunology Today·J W StreileinB R Ksander
Oct 1, 1990·International Ophthalmology·J W StreileinJ S Williamson
Apr 12, 2008·BMC Genetics·Michael G AndersonSimon W M John
Jan 17, 2009·The American Journal of Pathology·Hong QiaoJoan Stein-Streilein
Nov 3, 1998·Ocular Immunology and Inflammation·S Okamoto, J W Streilein

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