PMID: 2104183Jan 1, 1990Paper

Induction of diabetes in PVG/c strain rats by manipulation of the immune system

Autoimmunity
W J PenhaleD W Pethick

Abstract

A combination of thymectomy and sublethal irradiation (Tx-X) consistently induced diabetes in female rats of the PVG/c strain. The incidence of diabetes varied from 10.7% to 53.4% in seven successive Tx-X groups (mean 29.7%). Both clinical and subclinical disease was observed with the majority of affected animals developing the former condition. This was acute in onset, rapidly fatal (1-4 days) and characterized by ketosis and lipidemia. Overtly diabetic rats had markedly raised plasma glucose concentrations compared to normal rats of the same strain and plasma immunoreactive insulin concentrations were correspondingly depressed in this group. Histopathological change within the islets of Langerhans correlated with clinical status and ranged from diffuse atrophy in the majority of the acutely diabetic rats to mild and focal lymphocytic insulitis in a proportion of the non-diabetic rats. Islet cell autoantibodies were demonstrated by indirect immunofluorescence in approximately 25% of clinically diabetic animals. The majority of diabetic rats were found to be responsive to insulin and the clinical signs could be reversed by daily parenteral insulin administration. These observations implicate the immune system in diabetes genera...Continue Reading

References

Sep 1, 1982·Diabetes·A A LikeA A Rossini
Jan 1, 1981·The American Journal of Medicine·J Nerup, A Lernmark

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Citations

Apr 1, 1992·Diabetes/metabolism Reviews·L CrisáA A Rossini
Feb 12, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·John P MordesElizabeth P Blankenhorn
Jul 2, 2004·ILAR Journal·John P MordesDale L Greiner
Feb 1, 1996·Immunological Reviews·P A GleesonI R van Driel
Jun 3, 2000·Annual Review of Immunology·E M Shevach
May 28, 2008·Transplant Immunology·Toshiaki NakanoChao-Long Chen
Nov 1, 2007·European Journal of Immunology·Shimon SakaguchiMakoto Miyara
May 18, 1999·The Journal of Allergy and Clinical Immunology·R GerliC Franceschi
Sep 28, 2002·Diabetes·Sheela RamanathanPhilippe Poussier
Apr 25, 2008·Current Protocols in Immunology·S Simmonds, D Mason
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paola RomagnoliJoost P M van Meerwijk

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