PMID: 6969145May 1, 1980Paper

Induction of differentiation in human marrow T cell precursors by the synthetic serum thymic factor, FTS

Clinical and Experimental Immunology
G S IncefyR A Good

Abstract

The serum thymic factor, 'facteur thymique serique' (FTS), was analysed in vitro for its ability to induce differentiation of normal human marrow T cell precursors into cells with T lymphocyte characteristics. FTS has been isolated, characterized, sequenced and synthesized. In the mouse, natural and synthetic FTS have similar activities in vitro in the rosette inhibition assay. Both substances influence a variety of T cell differentiation markers and functions in vivo. In this study, we found that synthetic FTS induced appearance of two T cell surface markers, HTLA phenotypes and the ability to form E rosettes, on a selective population of normal human marrow cells sedimenting in layers II or III of a Ficoll discontinuous density gradient. In addition, a population of lymphoid cells also found in layer III, which bears receptors for peanut agglutinin (PNA), was decreased in number following exposure to FTS. In the same gradient layer, cells which expressed terminal deoxyribonucleotidyl transferase (TdT) activity showed decreased activity after treatment with FTS. Functional activities characteristic of T lymphocytes were also enhanced in marrow cells of gradient layer III after preincubation with FTS. These T cell functions wer...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.