PMID: 11933111Apr 5, 2002Paper

Induction of differentiation in rat C6 glioma cells with Saikosaponins

Phytotherapy Research : PTR
Yan-Jyu TsaiRong-Tsun Wu

Abstract

The effects of saikosaponins (a, b(1), b(2), c, d), isolated from Bupleurum Radix, on the induction of differentiation in rat C6 glioma cells were studied. Saikosaponins a and d were shown to inhibit cell proliferation and alter cell morphology. In addition to cytostasis, the enzymatic activities of glutamine synthetase (GS) and 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) were also noticeably increased after treatment with saikosaponin a. Nevertheless, saikosaponin d only showed an increase of GS activity, no significant changes in CNP activity were found. These results suggest that saikosaponin a can induce the differentiation of C6 glioma cells into astrocytes and/or oligodendrocytes, but saikosaponin d can only induce the differentiation of C6 glioma cells into astrocytes.

References

Mar 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M D Norenberg
Jan 1, 1975·Journal of the Chemical Society. Perkin Transactions 1·A ShimaokaH Minato
Aug 1, 1985·The Journal of Pharmacy and Pharmacology·H AbeS Odashima
Sep 1, 1970·The Biochemical Journal·K Iqbal, J H Ottaway
Mar 1, 1972·Journal of Neurochemistry·S E Poduslo, W T Norton
Jul 26, 1968·Science·P BendaW Sweet
Apr 1, 1980·Journal of Neurochemistry·M R Pishak, A T Phillips
Apr 11, 1980·Science·K K ParkerA Vernadakis

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Citations

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Nov 18, 2006·Journal of Zhejiang University. Science. B·Wen-jing RuanJian-guang Zhou
Sep 27, 2014·BMC Complementary and Alternative Medicine·Ruizhi ZhaoZhicai Xiao
Jun 20, 2006·Biochemical and Biophysical Research Communications·Osamu MorinagaYukihiro Shoyama
Jun 5, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xin SuiZhi-Dong Qiu
Apr 29, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Rui-Ping Ye, Zhen-Dong Chen
Oct 27, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao-Huang XuJin-Jian Lu
Jan 2, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Guoqiang LiuZunjian Zhang
Jun 20, 2013·Journal of Neuro-oncology·Ying YinChunxing Liu
Jun 1, 2018·Oxidative Medicine and Cellular Longevity·Byeong Mo Kim
Jan 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuli YanYuxin Li
May 7, 2009·Molecular Cancer Therapeutics·Danijela Maksimovic-IvanicFerdinando Nicoletti
Oct 30, 2021·Pharmaceutical Biology·Piao ZhouJing Guo
Sep 10, 2017·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wen-Feng ZhangMing-Hua Duan

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