Abstract
Ionizing radiation produces various types of DNA lesions, such as base damage, single-strand breaks, double-strand breaks (DSBs), and DNA-protein cross-links (DPCs). Of these, DSBs are the most critical lesions underlying the lethal effects of ionizing radiation. With DPCs, proteins covalently trapped in DNA constitute strong roadblocks to replication and transcription machineries, and hence can be lethal to cells. The formation of DPCs by ionizing radiation is promoted in the absence of oxygen, whereas that of DSBs is retarded. Accordingly, the contribution of DPCs to the lethal events in irradiated cells may not be negligible for hypoxic cells, such as those present in tumors. However, the role of DPCs in the lethal effects of ionizing radiation remains largely equivocal. In the present study, normoxic and hypoxic mouse tumors were irradiated with X-rays [low linear energy transfer (LET) radiation] and carbon (C)-ion beams (high LET radiation), and the resulting induction of DPCs and DSBs and their removal from the genome were analyzed. X-rays and C-ion beams produced more DPCs in hypoxic tumors than in normoxic tumors. Interestingly, the yield of DPCs was slightly but statistically significantly greater (1.3- to 1.5-fold) fo...Continue Reading
References
Aug 16, 1977·Biochimica Et Biophysica Acta·A J Fornace, J B Little
Aug 15, 1992·Archives of Biochemistry and Biophysics·R OlinskiM Dizdaroglu
Aug 1, 1992·Carcinogenesis·A Zhitkovich, M Costa
Jan 30, 1990·Biochemistry·E Gajewski, M Dizdaroglu
Jan 1, 1990·Radiation and Environmental Biophysics·M Frankenberg-Schwager
Apr 18, 1989·Biochemistry·M DizdarogluS A Margolis
Jul 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·K EguchiI Kaneko
Jun 1, 1995·Radiation and Environmental Biophysics·G Taucher-ScholzG Kraft
Jan 1, 1994·Radiation and Environmental Biophysics·M SchneiderG Kraft
Nov 1, 1994·International Journal of Radiation Biology·J F Ward
Sep 1, 1999·Free Radical Biology & Medicine·T S CharltonM W Duncan
Nov 18, 2000·Mutation Research·O MerkG Speit
Oct 18, 2001·Radiation Research·H NikjooD T Goodhead
Nov 26, 2003·Mutation Research·Jean CadetJean-Luc Ravanat
Mar 30, 2005·Mutation Research·Sharon BarkerDavid Murray
Aug 12, 2005·The Journal of Biological Chemistry·Sharon BarkerDavid Murray
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Joyce T Reardon, Aziz Sancar
Apr 28, 2006·Journal of the American Chemical Society·Sandrine PerrierJean-Luc Ravanat
May 18, 2007·The Journal of Biological Chemistry·David J BakerTimothy R O'Connor
Sep 1, 2007·Biochemistry·Chad C Bjorklund, William B Davis
Sep 7, 2007·Cancer Research·H Kenny KuoKenneth N Kreuzer
Aug 5, 2008·DNA Repair·Zhiyong MaoVera Gorbunova
Aug 14, 2009·The Journal of Biological Chemistry·Toshiaki NakanoHiroshi Ide
Dec 15, 2010·Radiation Protection Dosimetry·R HirayamaY Furusawa
Dec 28, 2010·Mutation Research·Hiroshi IdeAmir M H Salem
Jan 12, 2012·The Journal of Biological Chemistry·Toshiaki NakanoHiroshi Ide
Feb 2, 2012·Cancer Letters·Miral Dizdaroglu
May 1, 2012·Cancer Letters·Jean CadetDimitar Angelov
Jun 26, 2012·Nucleic Acids Research·Mahmoud I ShoulkamyHiroshi Ide
Jan 4, 2013·The Journal of Biological Chemistry·Toshiaki NakanoHiroshi Ide
Jun 6, 2013·Mutation Research·Ryoichi HirayamaYoshiya Furusawa
Feb 25, 2014·Free Radical Biology & Medicine·Andrew B DasPéter Nagy
Citations
Feb 27, 2016·Mutation Research·Ming-Zhang XieHiroshi Ide
Jul 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jason L QuiñonesBruce Demple
Oct 3, 2015·Radiation Research·Naoto ShimizuKouji Hirota
Jul 31, 2016·Radiation Oncology·Taito AsahinaMasahiko Miura
Jan 20, 2018·Antioxidants & Redox Signaling·Jean-Pierre PougetJean-Luc Ravanat
May 4, 2018·Free Radical Research·Li GuoMichael G Kong
Nov 27, 2018·Journal of Radiation Research·Yoshihiko HagiwaraAtsushi Shibata
Feb 13, 2019·Journal of Bacteriology·Fernando Santos-EscobarMario Pedraza-Reyes
Jun 27, 2020·PloS One·Toshiaki NakanoKeizo Tano
Jan 24, 2019·Dose-response : a Publication of International Hormesis Society·Yu GaoYumin Lyu
Aug 28, 2020·Frontiers in Genetics·Ilya O VelegzhaninovDmitry Yu Klokov
May 7, 2021·Biochimica Et Biophysica Acta. Proteins and Proteomics·Xiaoying WeiKun Yang
Sep 26, 2021·Journal of Radiation Research·Masataka TsudaHiroshi Ide