Induction of donor-specific unresponsiveness by intrathymic islet transplantation

Science
A M PosseltA Naji

Abstract

The application of isolated pancreatic islet transplantation for treatment of diabetes mellitus has been hampered by the vulnerability of islet allografts to immunologic rejection. Rat islet allografts that were transplanted into the thymus of recipients treated with a single injection of anti-lymphocyte serum survived indefinitely. A state of donor-specific unresponsiveness was achieved that permitted survival of a second donor strain islet allograft transplanted to an extrathymic site. Maturation of T cell precursors in a thymic microenvironment that is harboring foreign alloantigen may induce the selective unresponsiveness. This model provides an approach for pancreatic islet transplantation and a potential strategy for specific modification of the peripheral immune repertoire.

References

Mar 23, 1990·Science·J SalaünN M Le Douarin
Jul 1, 1988·The Journal of Experimental Medicine·R P Shimonkevitz, M J Bevan
Nov 1, 1988·The Journal of Experimental Medicine·S A MichieR V Rouse
Sep 1, 1972·The Journal of Experimental Medicine·E Raviola, M J Karnovsky
May 4, 1973·Nature·H Cantor, R Asofsky
Jan 1, 1984·Annual Review of Immunology·P E Lacy, J M Davie
Jan 1, 1983·Annual Review of Immunology·K J LaffertyH S Warren
Jan 1, 1980·Diabetes·C F BarkerW K Silvers

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Citations

Dec 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A M Krensky, C Clayberger
Jan 1, 1997·International Journal of Clinical & Laboratory Research·N Perico, G Remuzzi
Jan 1, 1993·Immunologic Research·J M Cruse, R E Lewis
Nov 5, 1997·Diabetologia·N M DesaiK J Lafferty
Sep 17, 2004·Transplant International : Official Journal of the European Society for Organ Transplantation·Bernd M SpriewaldKathryn J Wood
Jul 27, 2011·Current Diabetes Reports·Elisa Cantarelli, Lorenzo Piemonti
Sep 5, 1992·Lancet·A M PosseltC F Barker
Oct 1, 1994·Veterinary Immunology and Immunopathology·T KenmochiE Stein
Jan 1, 1992·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S J Sullivan
Oct 1, 1991·Current Opinion in Immunology·K J Wood
Oct 1, 1992·Current Opinion in Immunology·M D Pescovitz
Dec 1, 1993·Current Opinion in Immunology·A Cooke, D C Wraith
Oct 1, 1993·Current Opinion in Immunology·H Waldmann, S Cobbold
Oct 1, 1994·Current Opinion in Immunology·A M Krensky, C Clayberger
Feb 1, 1997·Transplantation Proceedings·M CarmelliniR Navalesi
Feb 1, 1997·Transplantation Proceedings·N C ChowdhuryS F Oluwole
Jun 1, 1997·Transplantation Proceedings·S Del GuerraP Marchetti
Jun 1, 1997·Transplantation Proceedings·B E BuckT I Malinin
Sep 2, 1998·Transplantation Proceedings·P J Morris
Sep 2, 1998·Transplantation Proceedings·M CarmelliniF Mosca
Dec 5, 1998·Transplantation Proceedings·R SumimotoK Dohi
Mar 20, 1999·Transplantation Proceedings·Y AkamatsuS Satomi
Mar 20, 1999·Transplantation Proceedings·B E TuchA N Pinto
Nov 22, 1997·Current Opinion in Immunology·R Lechler, J A Bluestone
Nov 22, 1997·Current Opinion in Immunology·K J Wood
Aug 16, 2002·Transplant Immunology·D ChenJ S Bromberg
Aug 5, 2005·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Sandra S SandsRobert J Ketchum

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