PMID: 6113147Jan 1, 1981Paper

Induction of drug metabolizing enzymes by sulfinpyrazone

European Journal of Clinical Pharmacology
E WalterE Weber

Abstract

A previous interaction study of sulfinpyrazone (Anturano) suggested that it induced microsomal drug metabolizing enzymes in the liver. To verify this finding the effect of sulfinpyrazone 800 mg per day for four weeks was investigated in ten healthy volunteers. Both the therapeutic actions of sulfinpyrazone, the uricosuric and the antiaggregating effects, were demonstrated (p less than 0.05). The influence on the microsomal drug metabolizing system in the liver was demonstrated by an increase in serum-gamma-glutamyl transpeptidase from 15.1 to 23.3 U/l (p greater than 0.05), a significant increase in the urinary excretion of d-glucaric acid (29.6 to 77.9 microMol/24 h, p less than 0.05) and an increase in antipyrine clearance from 50.3 ml/min to 83.9 ml/min (p less than 0.05). The possibility of enhancement of drug metabolism during treatment with sulfinpyrazone in combination with other drugs should be kept in mind.

References

Feb 9, 1978·The New England Journal of Medicine·UNKNOWN Anturane Reinfarction Trial Research Group
Jul 13, 1978·The New England Journal of Medicine·UNKNOWN Canadian Cooperative Study Group
Dec 1, 1975·British Journal of Clinical Pharmacology·D S Lecamwasam
Aug 23, 1974·European Journal of Clinical Pharmacology·S LindgrenF Sjöqvist
Jul 5, 1968·Science·E S Vesell, J G Page
Nov 1, 1980·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·C StaigerE Walter
Jun 1, 1974·British Journal of Clinical Pharmacology·M DavisR Williams

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Citations

Jan 1, 1982·European Journal of Clinical Pharmacology·J O MinersD J Birkett
Jan 1, 1983·European Journal of Clinical Pharmacology·B RosenkranzJ C Frölich
Nov 15, 1982·Klinische Wochenschrift·E WalterK Jüngling
May 1, 1983·British Journal of Industrial Medicine·M Døssing
Jul 1, 1984·British Journal of Clinical Pharmacology·J GodbillonJ P Fillastre

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