Abstract
A male infant with partial DiGeorge syndrome responded to weekly administration of levamisole (2.5 mg/kg of body weight) with an increase of circulating E-rosette-forming T cells. Thymic hormone activity in plasma appeared to be elevated to a near-normal level of 11.6 ng thymopoietin equivalent/ml after levamisole administration. The in vitro incubation studies indicated that levamisole by itself had no E-rosette-promoting ability, but a dialysable and relatively heat-stable plasma factor induced by levamisole both in the patient and in healthy individuals had E-rosette-promoting activity for the patient's lymphocytes. Such a plasma factor, however, could not be induced in all four thymectomized myasthenic subjects examined, suggesting a thymus-dependent nature of the plasma factor. These results suggest that levamisole might mediate an increased secretion of humoral factor(s) with E-rosette-promoting activity, even from such a rudimentary thymus as in the partial DiGeorge syndrome.
References
May 15, 1976·Lancet·I A Williams
Sep 3, 1977·Lancet·V LewisP Bealmear
Jan 1, 1979·Scandinavian Journal of Immunology·N MoriyaN Taniguchi
Feb 28, 1975·Annals of the New York Academy of Sciences·G Goldstein
Feb 1, 1977·The Journal of Experimental Medicine·G Renoux, M Renoux
Jan 1, 1978·Scandinavian Journal of Immunology·T NagaokiN Taniguchi
Jul 1, 1979·Pediatric Research·F AiutiL Businco
Apr 1, 1979·The American Journal of Medicine·J J TwomeyR A Good
Jun 1, 1979·The Journal of Pediatrics·M E ConleyL Tenckhoff
Sep 1, 1977·Clinical and Experimental Dermatology·A P Warin, E W Jones
Jan 9, 1975·The New England Journal of Medicine·D W WaraA J Ammann
Nov 15, 1969·Lancet·H W Lischner, A M DiGeorge
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A L GoldsteinA White
Oct 19, 1972·The New England Journal of Medicine·R W SteeleJ A Bellanti
Jul 1, 1980·The Journal of Pediatrics·D J BarrettM J Cowan