Induction of EGF receptor and erbB-2 during endotoxin-induced alveolar type II cell proliferation in the rat lung

International Journal of Experimental Pathology
J TesfaigziJ F Lechner

Abstract

The overall purpose of this study was to produce a model of transient type II cell hyperplasia to enable comparisons of changes in gene expression in the remodelling epithelium with those in carcinogen-induced hyperplastic lesions. Rats instilled with endotoxin had increased numbers of neutrophils in the bronchoalveolar lavage fluid (BALF) by 3 hours that reached maximum levels at 48 hours and returned to background levels 168 hours after instillation. The number of macrophages in the BALF increased throughout the 168 hours following instillation. Epithelial cell hyperplasia was maximum at 96 hours post-instillation in areas of extensive inflammation. The number of alveolar epithelial cells that exhibited bromodeoxyuridine nuclear incorporation reached maximum levels 48 hours after endotoxin treatment and decreased to near background levels at 96 hours. Ultrastructural studies of hyperplastic cells showed the presence of lamellar bodies and condensed chromosomes, characteristics of type II cells in mitosis. At 168 hours after instillation, the hyperplasia regressed to form normal-appearing alveolar structure with few focal lesions. Specific immunostaining for the proto-oncogenes, EGF receptor and erbB-2, on tissue sections incr...Continue Reading

Citations

Jun 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nicolau BeckmannJohn R Fozard
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yohannes TesfaigziJulie A Wilder
Apr 22, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jennifer E FosterYohannes Tesfaigzi
Sep 10, 2004·The Journal of Biological Chemistry·Sander H DiksMaikel P Peppelenbosch
Jan 28, 2006·American Journal of Respiratory Cell and Molecular Biology·Yohannes Tesfaigzi
Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·Y TesfaigziJ Seagrave
Feb 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L M HamiltonD E Davies
May 29, 2004·Anti-cancer Drugs·Shin-ichiro InomataShosaku Abe
Feb 26, 2005·Journal of Applied Physiology·David E NetheryJeffrey A Kern
Aug 5, 1998·The American Journal of Physiology·S I DantoR L Lubman
Feb 11, 2021·Cells·Amanda Croasdell LucchiniChristopher D Lucas

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