Induction of experimental autoimmune thyroiditis in mice with in vitro activated splenic T cells

Cellular Immunology
H Braley-MullenM Kyriakos

Abstract

Spleen cells from CBA/J or SJL mice sensitized with mouse thyroglobulin (MTg) and lipopolysaccharide (LPS) could be activated in vitro with MTg to transfer experimental autoimmune thyroiditis (EAT) to normal syngeneic recipients. EAT induced by these transferred cells was similar in incidence and severity to EAT induced by active immunization of mice with MTg and adjuvant and cells from EAT-resistant Balb/c mice could not be activated to induce EAT. The specific antigen MTg was required both for initial sensitization of the mice and for activation of spleen cells in vitro. The cells that were active in transferring EAT to mice were shown to be T cells. Removal of B cells from the cultured spleen cells had no effect on the ability of the cells to induce EAT.

Citations

Jun 26, 1999·European Journal of Immunology·P ZacconeA Cooke
Jan 1, 1986·Immunologic Research·G W CanonicaY M Kong
Jan 15, 1989·Immunology Letters·L S RayfieldL A Bergmeier
Feb 1, 1997·Immunology Today·George Carayanniotis, V P Rao
Jun 16, 1988·The New England Journal of Medicine·M B AtkinsM M Kaplan
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Francesca MenconiYaron Tomer
Mar 1, 1992·The Journal of Experimental Medicine·P R HutchingsI M Roitt
Dec 19, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·W FondalH Braley-Mullen
Oct 4, 2007·Thyroid : Official Journal of the American Thyroid Association·Yujiang FangH Braley-Mullen
Mar 1, 1997·Immunology·George CarayanniotisR J Noelle
Dec 1, 1990·Journal of Immunogenetics·C J KrcoY M Kong
Mar 15, 2005·Journal of Autoimmune Diseases·Dimitry A Chistiakov
Jan 27, 2009·Critical Reviews in Immunology·Jeremy P McAleer, Anthony T Vella
May 24, 2011·Journal of Thyroid Research·Rajni B SharmaC Lynne Burek
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yoshiyuki BanYaron Tomer
May 10, 2008·The American Journal of Pathology·Yujiang FangH Braley-Mullen
Nov 1, 1987·Cellular Immunology·W V WilliamsH Braley-Mullen
Sep 24, 2008·The Journal of Pathology·Yujiang FangH Braley-Mullen
May 1, 1999·Journal of Autoimmunity·H Braley-MullenH Tang
Nov 5, 1997·Clinical Immunology and Immunopathology·Patrizio CaturegliN R Rose
Dec 9, 2014·International Journal of Molecular Medicine·Zhenqian YuWeiping Teng
Oct 5, 2013·Endocrine Reviews·Sandra M McLachlan, Basil Rapoport
Dec 29, 2000·International Reviews of Immunology·E A Stafford, N R Rose
Dec 29, 2000·International Reviews of Immunology·H Braley-Mullen, G C Sharp
Jan 15, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Panayota KolypetriGeorge Carayanniotis
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H Braley-Mullen, Shiguang Yu
Jan 12, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shiguang YuH Braley-Mullen
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K ChenH Braley-Mullen
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F BatteuxG Chiocchia

Related Concepts

Metazoa
Antigens
Autoimmune Diseases
Cell Division Phases
Normal Serum Globulin Therapy
Lipopolysaccharides
Lymph Nodes
Lymphocyte Activation
Mice, Inbred Strains
Spleen

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.