Abstract
Expression levels of growth factor receptors are subject to complex regulation, which is of consequence for their signaling capacity in physiological and pathological processes. We examined the regulation of expression levels of fibroblast growth factor receptor 1 (FGFR-1) in human fibroblasts treated with a panel of growth regulatory factors. Only platelet-derived growth factor BB (PDGF-BB) treatment had a significant effect and induced FGFR-1 mRNA levels fourfold, with a peak around 8 h of stimulation. The increase in mRNA levels was followed by an increased synthesis of FGFR-1 protein, which responded to basic FGF (bFGF) stimulation with induction of kinase activity and biological signaling. Thus, murine brain endothelial cells displayed an augmented induction of plasminogen activator activity in response to bFGF, following treatment with PDGF-BB. These data suggest that PDGF-BB could support FGFR-1-mediated biological responses in processes such as angiogenesis.
Citations
Jan 2, 2001·Mediators of Inflammation·M SasakiM Miura
Nov 9, 2005·DNA and Cell Biology·Paul Y LiuIan C Summerhayes
Jan 12, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Areck A UcuzianHoward P Greisler
Jan 28, 1999·American Journal of Respiratory Cell and Molecular Biology·W A Price
Feb 15, 2003·FEBS Letters·Hisaki HayashiToru Imamura
Aug 19, 2000·Molecular Therapy : the Journal of the American Society of Gene Therapy·L A ChandlerG F Pierce
Dec 24, 1997·Circulation·J Waltenberger
Jul 31, 2008·Pancreas·Guowei ChenMarko Kornmann
Jan 4, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Bernhard WitzenbichlerJeffrey M Isner
Feb 22, 2012·Journal of Pharmacological Sciences·Kyu-Dong YooYeo-Pyo Yun
Jun 11, 2005·World Journal of Gastroenterology : WJG·Atsushi MasamuneTooru Shimosegawa
Dec 18, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yun-Ui BaeJae-Ryong Kim
Oct 9, 2002·Oncogene·Yasushi MochizukiShigeru Kanda
Nov 2, 1999·Medizinische Klinik·S RosenkranzA Kazlauskas
Jun 21, 2021·Chinese Medicine·Li ZhangPeng Chen