Induction of foci of altered hepatocytes by a single injection of azaserine to rats

Cancer Letters
S TakahashiH Shinozuka


The induction of foci of altered, gamma-glutamyltranspeptidase (GGT)-positive hepatocytes by azaserine was investigated. After injection of a single dose of azaserine, many foci developed in male Wistar rats fed a choline-devoid (CD) diet containing acetylaminofluorene (AAF), but only a few in rats fed a choline-supplemented (CS) diet containing AAF. Similar results were obtained in rats fed a plain CD diet or a plain CS diet and injected with a single dose of azaserine after a partial hepatectomy. These findings indicate that azaserine is an effective initiator of liver carcinogenesis in rats, and that a CD diet acts as a strong promoter of the evolution initiated liver cells to foci of altered, GGT-positive hepatocytes.


Jul 15, 1978·International Journal of Cancer. Journal International Du Cancer·H ShinozukaB Lombardi
Apr 15, 1979·International Journal of Cancer. Journal International Du Cancer·B Lombardi, H Shinozuka
Aug 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A M RutenburgA M Seligman

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Gamma-glutamyl transferase
Hepatoma, Novikoff
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Choline Hydroxide
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