PMID: 9541657Apr 29, 1998Paper

Induction of forward mutations at the thymidine kinase locus of mouse lymphoma cells: evidence for electrophilic and non-electrophilic mechanisms

Mutation Research
B HenryH S Rosenkranz

Abstract

A database of 209 chemicals tested for induction of forward mutations at the heterozygous thymidine kinase (TK +/-) locus in L5178Y mouse lymphoma cells was analyzed for structure-activity relationships using the MultiCASE expert system. Consistent with evidence of several contributing biological mechanisms, these studies suggest that such mutations may occur by more than one mechanism. As might be expected, there was evidence for a component involving direct electrophilic attack on the cellular DNA, in a manner previously established as causative in the induction of mutations in Salmonella. In addition, however, there was also strong evidence for another mechanism or mechanisms involving chromosome missegregation, cellular toxicity or an alternate site of action, such as the microtubules.

References

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Citations

Oct 6, 1999·Teratology·J GómezH S Rosenkranz
Dec 5, 1998·Mutation Research·H S RosenkranzG Klopman
Mar 10, 2000·Mutation Research·S G GrantH S Rosenkranz
Nov 24, 2005·Environmental and Molecular Mutagenesis·Constantinos AndrianopoulosNikos A Demopoulos
Nov 21, 2000·Statistical Methods in Medical Research·C HelmaS Kramer
Jul 1, 2000·Alternatives to Laboratory Animals : ATLA·X Zhu, H S Rosenkranz
Sep 24, 1999·SAR and QSAR in Environmental Research·H S RosenkranzG Klopman

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